Technology Process of 6-(benzyloxy)-1-(3-(benzyloxy)-2-fluorobenzyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
There total 12 articles about 6-(benzyloxy)-1-(3-(benzyloxy)-2-fluorobenzyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-(3-(benzyloxy)-2-fluorophenyl)-N-(3-(benzyloxy)-4-methoxyphenethyl)-N-methylacetamide;
With
trichlorophosphate;
In
acetonitrile;
for 3h;
Inert atmosphere;
Reflux;
With
methanol; sodium tetrahydroborate;
at 20 ℃;
for 16h;
Inert atmosphere;
Cooling with ice;
DOI:10.1002/chem.201201895
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydroxide; sodium tetrahydroborate; diphenyl diselenide / ethanol / 20 - 40 °C / Inert atmosphere
2.1: bromic acid / water / 5 h / 105 °C
3.1: sodium iodide; potassium hydroxide / ethanol / 20 °C
4.1: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 3 h
5.1: sodium hydroxide / chloroform; water / 16 h / 20 °C / Cooling with ice
6.1: trichlorophosphate / acetonitrile / 3 h / Inert atmosphere; Reflux
6.2: 16 h / 20 °C / Inert atmosphere; Cooling with ice
With
sodium tetrahydroborate; oxalyl dichloride; diphenyl diselenide; bromic acid; N,N-dimethyl-formamide; sodium iodide; potassium hydroxide; sodium hydroxide; trichlorophosphate;
In
ethanol; chloroform; water; toluene; acetonitrile;
DOI:10.1002/chem.201201895
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium iodide; potassium hydroxide / ethanol / 20 °C
2.1: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 3 h
3.1: sodium hydroxide / chloroform; water / 16 h / 20 °C / Cooling with ice
4.1: trichlorophosphate / acetonitrile / 3 h / Inert atmosphere; Reflux
4.2: 16 h / 20 °C / Inert atmosphere; Cooling with ice
With
oxalyl dichloride; N,N-dimethyl-formamide; sodium iodide; potassium hydroxide; sodium hydroxide; trichlorophosphate;
In
ethanol; chloroform; water; toluene; acetonitrile;
DOI:10.1002/chem.201201895