2-fluoro-2-(2-fluorobiphenyl-4-yl)acetic acid

Base Information

• Chemical Name: 2-fluoro-2-(2-fluorobiphenyl-4-yl)acetic acid
• CAS No.: 1279100-88-7
• Molecular Formula: C₁₄H₁₀F₂O₂
• Molecular Weight: 248.229
• Mol file: 1279100-88-7.mol

Synonyms:2-fluoro-2-(2-fluorobiphenyl-4-yl)acetic acid

Chemical Property of 2-fluoro-2-(2-fluorobiphenyl-4-yl)acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-fluoro-2-(2-fluorobiphenyl-4-yl)acetic acid

There total 2 articles about 2-fluoro-2-(2-fluorobiphenyl-4-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-( 4-bromo-3-fluorophenyl)acetonitrile (499983-13-0) → 2-fluoro-2-(2-fluorobiphenyl-4-yl)acetic acid (1279100-88-7)

Guidance literature:

Multi-step reaction with 4 steps

1: tetrabutylammomium bromide; palladium diacetate; sodium carbonate / water / 120 °C / Inert atmosphere

2: dihydrogen peroxide; potassium carbonate / dimethyl sulfoxide / 0 °C / Inert atmosphere

3: lithium hexamethyldisilazane / tetrahydrofuran / 0 - 25 °C

4: 1-(chloromethyl)-4-fluoro-1,4-diazabicyclo[2.2.2]octane-1,4-diium tetrafluoroborate / acetonitrile / 25 - 50 °C / Inert atmosphere

With 1-(chloromethyl)-4-fluoro-1,4-diazabicyclo[2.2.2]octane-1,4-diium tetrafluoroborate; tetrabutylammomium bromide; dihydrogen peroxide; palladium diacetate; sodium carbonate; potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; water; dimethyl sulfoxide; acetonitrile; 1: Suzuki coupling;

DOI:10.1021/jm101450p

Reference yield:

2-(2-fluoro-[1,1'-biphenyl]-4-yl)acetic acid (5001-96-7) → 2-fluoro-2-(2-fluorobiphenyl-4-yl)acetic acid (1279100-88-7)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 0 - 25 °C

2: 1-(chloromethyl)-4-fluoro-1,4-diazabicyclo[2.2.2]octane-1,4-diium tetrafluoroborate / acetonitrile / 25 - 50 °C / Inert atmosphere

With 1-(chloromethyl)-4-fluoro-1,4-diazabicyclo[2.2.2]octane-1,4-diium tetrafluoroborate; lithium hexamethyldisilazane; In tetrahydrofuran; acetonitrile;

DOI:10.1021/jm101450p

upstream raw materials:

2-( 4-bromo-3-fluorophenyl)acetonitrile

2-(2-fluoro-[1,1'-biphenyl]-4-yl)acetic acid

Refernces