4-methyl-2-methylene valeric acid

Base Information

• Chemical Name: 4-methyl-2-methylene valeric acid
• CAS No.: 25044-10-4
• Molecular Formula: C7H12 O2
• Molecular Weight: 128.171
• Hs Code.: 2916190090
• Mol file: 25044-10-4.mol

Synonyms:Valericacid, 4-methyl-2-methylene- (8CI); 4-Methyl-2-methylenepentanoic acid

Chemical Property of 4-methyl-2-methylene valeric acid

Chemical Property:

• Vapor Pressure: 0.0623mmHg at 25°C
• Boiling Point: 213.9°Cat760mmHg
• Flash Point: 120.4°C
• PSA: 37.30000
• Density: 0.956g/cm³
• LogP: 1.67330

Purity/Quality:

99% ^*data from raw suppliers

4-Methyl-2-methylenevalericacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-methyl-2-methylene valeric acid

There total 11 articles about 4-methyl-2-methylene valeric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + isobutylmalonic Acid (4361-06-2) → 2-methylene-4-methyl-pentanoic acid (25044-10-4)

Guidance literature:

isobutylmalonic Acid; With diethylamine; In ethyl acetate; at 0 - 23 ℃; Reflux; Inert atmosphere;

formaldehyd; In ethyl acetate; for 5h; Reflux; Inert atmosphere;

DOI:10.1021/ja806021y

Reference yield: 99.0%

ethyl 2-isobutylacrylate (87438-94-6) → 2-methylene-4-methyl-pentanoic acid (25044-10-4)

Guidance literature:

ethyl 2-isobutylacrylate; With water; potassium hydroxide; Reflux;

With hydrogenchloride; In water; pH=5 - 6;

Reference yield: 88.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + isobutylmalonic Acid (4361-06-2) + diethylamine (109-89-7) → 2-methylene-4-methyl-pentanoic acid (25044-10-4)

Guidance literature:

With hydrogenchloride; In ethyl acetate;

upstream raw materials:

4-methyl-2-methylenepentanal

formaldehyd

isobutylmalonic Acid

(2-methylpropyl)-propanedioic acid, diethyl ester

Downstream raw materials:

4-Methyl-2-methylene-pentanoic acid 3,4-dimethoxy-benzyl ester

3-methylbutyric acid

2-[(1-Benzyloxycarbonylamino-2-naphthalen-2-yl-ethyl)-methoxy-phosphinoylmethyl]-4-methyl-pentanoic acid 3,4-dimethoxy-benzyl ester

(S)-2-{2-[(1-Benzyloxycarbonylamino-2-naphthalen-2-yl-ethyl)-methoxy-phosphinoylmethyl]-4-methyl-pentanoylamino}-3-(1H-indol-3-yl)-propionic acid methyl ester

Refernces

• 1、 Wilding, Birgit,Pasqua, A. Elisa,E. A. Chessum, Nicola,Pierrat, Olivier A.,Hahner, Tamas,Tomlin, Kathy,Shehu, Erald,Burke, Rosemary,Richards, G. Meirion,Whitton, Bradleigh,Arwert, Esther N.,Thapaliya, Arjun,Salimraj, Ramya,van Montfort, Rob,Skawinska, Agi,Hayes, Angela,Raynaud, Florence,Chopra, Rajesh,Jones, Keith,Newton, Gary,Cheeseman, Matthew D.. "Investigating the phosphinic acid tripeptide mimetic DG013A as a tool compound inhibitor of the M1-aminopeptidase ERAP1". supporting information. . Retrieved 2021/05/06.
• 2、 -. "Bridged metallocene catalysts". Page/Page column. . Retrieved 2015/07/22.