Technology Process of 3-(3-chloro-4-(2,2-diethoxyethoxy)-5-methylphenyl)-5-(2-cyclopentyl-6-methoxypyridin-4-yl)-1,2,4-oxadiazole
There total 11 articles about 3-(3-chloro-4-(2,2-diethoxyethoxy)-5-methylphenyl)-5-(2-cyclopentyl-6-methoxypyridin-4-yl)-1,2,4-oxadiazole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydroxide; methanol / water / 4 h / 34 - 70 °C
1.2: 20 °C
2.1: sulfuric acid / methanol / 24 h / Reflux
3.1: bis[1,2-bis(diphenylphosphino)ferrocene]-palladium(0) / water; tetrahydrofuran / 3 h / 85 °C / Inert atmosphere
4.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.25 h / 20 °C
4.2: 22 h / 20 °C
With
methanol; sulfuric acid; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide;
bis[1,2-bis(diphenylphosphino)ferrocene]-palladium(0);
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: bis[1,2-bis(diphenylphosphino)ferrocene]-palladium(0) / water; tetrahydrofuran / 3 h / 85 °C / Inert atmosphere
2.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.25 h / 20 °C
2.2: 22 h / 20 °C
With
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine;
bis[1,2-bis(diphenylphosphino)ferrocene]-palladium(0);
In
tetrahydrofuran; water; N,N-dimethyl-formamide;
- Guidance literature:
-
2-cyclopentyl-6-methoxyisonicotinic acid methyl ester;
With
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.25h;
3-chloro-4-(2,2-diethoxyethoxy)-N-hydroxy-5-methylbenzimidamide;
With
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate;
at 20 ℃;
for 22h;