Azido-cyclohexyl-acetic acid

Base Information

• Chemical Name: Azido-cyclohexyl-acetic acid
• CAS No.: 158068-89-4
• Molecular Formula: C₈H₁₃N₃O₂
• Molecular Weight: 183.21
• Mol file: 158068-89-4.mol

Synonyms:Azido-cyclohexyl-acetic acid

Chemical Property of Azido-cyclohexyl-acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Azido-cyclohexyl-acetic acid

There total 4 articles about Azido-cyclohexyl-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Acetic acid 2-azido-1-cyano-2-cyclohexyl-1-methoxy-ethyl ester (1026191-15-0) → Azido-cyclohexyl-acetic acid (158068-89-4)

Guidance literature:

With water; potassium carbonate; In methanol; Yield given;

DOI:10.1016/S0040-4039(00)77143-7

Reference yield:

(Z)-3-Cyclohexyl-2-methoxy-acrylonitrile (158068-84-9) → Azido-cyclohexyl-acetic acid (158068-89-4)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium azide, ceric ammonium nitrate / acetonitrile / -15 - -5 °C

2: acetic acid / 1 h / 100 °C

3: potassium carbonate, water / methanol

With sodium azide; ammonium cerium(IV) nitrate; water; potassium carbonate; In methanol; acetic acid; acetonitrile;

DOI:10.1016/S0040-4039(00)77143-7

Reference yield:

3-Azido-3-cyclohexyl-2-methoxy-2-nitrooxy-propionitrile → Azido-cyclohexyl-acetic acid (158068-89-4)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / 1 h / 100 °C

2: potassium carbonate, water / methanol

With water; potassium carbonate; In methanol; acetic acid;

DOI:10.1016/S0040-4039(00)77143-7

upstream raw materials:

Acetic acid 2-azido-1-cyano-2-cyclohexyl-1-methoxy-ethyl ester

(Z)-3-Cyclohexyl-2-methoxy-acrylonitrile

cyclohexanecarbaldehyde

Downstream raw materials:

2-cyclohexylglycine

Refernces