Technology Process of methyl 7-(4-((2-phenylcyclopropyl)carbamoyl)phenoxy)-6-cyano-3,4-dihydro-2H-chromene-4-carboxylate
There total 9 articles about methyl 7-(4-((2-phenylcyclopropyl)carbamoyl)phenoxy)-6-cyano-3,4-dihydro-2H-chromene-4-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-(6-cyano-4-(methoxycarbonyl)chroman-7-yloxy)benzoic acid;
With
oxalyl dichloride; N,N-dimethyl-formamide;
In
dichloromethane;
at 20 ℃;
for 0.5h;
2-phenylcyclopropanamine hemisulfate;
With
triethylamine;
In
dichloromethane;
at 20 ℃;
for 17h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 1-methyl-pyrrolidin-2-one / 6 h / 160 °C / Inert atmosphere
2.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 18 h / 115 °C / Molecular sieve; Inert atmosphere
3.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C
4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C
4.2: 17 h / 20 °C
With
oxalyl dichloride; potassium carbonate; N,N-dimethyl-formamide; trifluoroacetic acid;
In
1-methyl-pyrrolidin-2-one; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 2.5 h / 50 °C
2.1: 1-methyl-pyrrolidin-2-one / 6 h / 160 °C / Inert atmosphere
3.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 18 h / 115 °C / Molecular sieve; Inert atmosphere
4.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C
5.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C
5.2: 17 h / 20 °C
With
N-Bromosuccinimide; oxalyl dichloride; potassium carbonate; N,N-dimethyl-formamide; trifluoroacetic acid;
In
1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide;