Technology Process of 1-{[5-Bromo-4-(3-chlorophenyl)thiophen-2-yl]carbonyl}imidazolidin-4-one
There total 5 articles about 1-{[5-Bromo-4-(3-chlorophenyl)thiophen-2-yl]carbonyl}imidazolidin-4-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sulfuric acid / Reflux
1.2: 20 °C
2.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium(0) / water; monoethylene glycol diethyl ether / 1.5 h / 80 °C / Inert atmosphere
3.1: bromine; acetic acid / 24 h / 60 °C
4.1: water; lithium hydroxide / tetrahydrofuran / 20 °C
5.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / tetrahydrofuran / 20 °C
With
sulfuric acid; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; bromine; sodium hydrogencarbonate; acetic acid; N-ethyl-N,N-diisopropylamine; lithium hydroxide;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; monoethylene glycol diethyl ether; water;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium(0) / water; monoethylene glycol diethyl ether / 1.5 h / 80 °C / Inert atmosphere
2: bromine; acetic acid / 24 h / 60 °C
3: water; lithium hydroxide / tetrahydrofuran / 20 °C
4: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / tetrahydrofuran / 20 °C
With
benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; bromine; sodium hydrogencarbonate; acetic acid; N-ethyl-N,N-diisopropylamine; lithium hydroxide;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; monoethylene glycol diethyl ether; water;