3-Pyridinepropanol

Base Information

• Chemical Name: 3-Pyridinepropanol
• CAS No.: 2859-67-8
• Molecular Formula: C8H11NO
• Molecular Weight: 137.181
• Hs Code.: 2933399090
• European Community (EC) Number: 220-675-7
• NSC Number: 66564
• DSSTox Substance ID: DTXSID5022198
• Nikkaji Number: J51.338E
• Wikidata: Q72503976
• ChEMBL ID: CHEMBL3229431
• Mol file: 2859-67-8.mol

Synonyms:3-Pyridinepropanol;2859-67-8;3-(Pyridin-3-Yl)Propan-1-Ol;3-Propanolpyridine;3-(3-PYRIDYL)-1-PROPANOL;3-pyridin-3-ylpropan-1-ol;3-(3-Hydroxypropyl)pyridine;3-(3-Pyridyl)propanol;3-(3-Pyridyl)propan-1-ol;EINECS 220-675-7;NSC 66564;BRN 0112609;3-Pyridin-3-yl-propan-1-ol;DTXSID5022198;5-21-02-00237 (Beilstein Handbook Reference);NSC66564;3-pyridine propanol;3-(3-pyridinyl)propanol;3-Pyridinepropanol, 98%;3-(pyridin-3-yl)propanol;3(3-pyridyl)-1-propanol;3-pyrid-3-ylpropan-1-ol;NCIOpen2_000152;3-(pyridin-3-yl)-propanol;SCHEMBL294520;3-(3-hydroxypropyl)-pyridine;3-(3-pyridyl)-1 -propanol;3-(3-pyridyl)-propan-1-ol;DTXCID302198;3-(Pyridin-3-yl)-1-propanol;CHEMBL3229431;3-(pyridine-3-yl)propan-1-ol;3-(3-Pyridinyl)-1-propanol #;Tox21_303737;MFCD00006414;NSC-66564;AKOS009031628;EG-0061;NCGC00357020-01;CAS-2859-67-8;LS-131912;CS-0186723;FT-0613616;P0350;EN300-20585;D84150;A848066;J-017133;Z104479004

Chemical Property of 3-Pyridinepropanol

Chemical Property:

• Vapor Pressure: 0.00144mmHg at 25°C
• Refractive Index: n20/D 1.53(lit.)
• Boiling Point: 283.999 °C at 760 mmHg
• PKA: 14.96±0.10(Predicted)
• Flash Point: 116.378 °C
• PSA: 33.12000
• Density: 1.059 g/cm³
• LogP: 1.00650
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 137.084063974
• Heavy Atom Count: 10
• Complexity: 85.3

Purity/Quality:

99% ^*data from raw suppliers

3-Pyridinepropanol >98.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC(=CN=C1)CCCO
• Uses: 3-(Pyridin-3-yl)propanol is a reagent in the synthesis of pyridylalcohols that exhibits hypoglycemic activity in fasted rats.

Technology Process of 3-Pyridinepropanol

There total 10 articles about 3-Pyridinepropanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

C16H30N2O*ClH → 3-(3-pyridyl)propan-1-ol (2859-67-8)

Guidance literature:

With ammonium acetate; In butan-1-ol; at 80 ℃;

DOI:10.1021/jo702311k

Reference yield: 79.0%

C11H15NO3 → 3-(3-pyridyl)propan-1-ol (2859-67-8)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 20 ℃; for 1h;

DOI:10.1016/j.tetlet.2013.11.074

Reference yield: 76.0%

3-iodopyridine (1120-90-7) + allyl alcohol (107-18-6) → 3-(3-pyridyl)propan-1-ol (2859-67-8)

Guidance literature:

With (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; ammonium chloride; In 2,2,2-trifluoroethanol; at 23 ℃; for 16h; Inert atmosphere; Irradiation;

DOI:10.1021/jacs.7b03262

upstream raw materials:

1,8-dioxa-1,4,5,6,7,8,9,10-octahydronaphthalene

3-Bromopyridine

3-(9-bora-bicyclo[3.3.1]non-9-yl)-propan-1-ol

methyl 3-(3-pyridyl)propanoate

Downstream raw materials:

C₉H₁₂O₃S*C₈H₁₂N₂O

3-[3-(4-Nitro-phenoxy)-propyl]-pyridine

3-(3-pyridyl)propyl phenylpropynoate

3-pyridine propionic acid

Refernces

• 1、 Boyington, Allyson J.,Riu, Martin-Louis Y.,Jui, Nathan T.. "Anti-Markovnikov Hydroarylation of Unactivated Olefins via Pyridyl Radical Intermediates". supporting information. p. 6582 - 6585. Retrieved 2017/05/29.
• 2、 Gadekar, Pradip K.,Hoermann, Maryann,Corbo, Faith,Sharma, Rajiv,Sarveswari,Roychowdhury, Abhijit. "Reductive removal of methoxyacetyl protective group using sodium borohydride". . p. 503 - 506. Retrieved 2014/01/06.