Hexestrol dimethyl ether

Base Information

• Chemical Name: Hexestrol dimethyl ether
• CAS No.: 130-78-9
• Molecular Formula: C20H26 O2
• Molecular Weight: 298.425
• Hs Code.: 2909309090
• European Community (EC) Number: 204-993-3
• NSC Number: 34403
• DSSTox Substance ID: DTXSID20926556
• Nikkaji Number: J184.375C
• Mol file: 130-78-9.mol

Synonyms:hexestrol dimethyl ether

Chemical Property of Hexestrol dimethyl ether

Chemical Property:

• Boiling Point: 390.7°Cat760mmHg
• Flash Point: 134.6°C
• PSA: 18.46000
• Density: 0.999g/cm³
• LogP: 5.39120
• XLogP3: 5.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 7
• Exact Mass: 298.193280068
• Heavy Atom Count: 22
• Complexity: 258

Purity/Quality:

98%min ^*data from raw suppliers

HEXESTROL DIMETHYL ETHER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(C1=CC=C(C=C1)OC)C(CC)C2=CC=C(C=C2)OC

Technology Process of Hexestrol dimethyl ether

There total 43 articles about Hexestrol dimethyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Diethylstilbestrol dimethyl ether (130-79-0) → racem.-3,4-bis-(4-methoxy-phenyl)-hexane (130-78-9,28199-75-9,28231-25-6,53584-73-9)

Guidance literature:

With palladium on activated charcoal; acetone; Hydrogenation;

DOI:10.1021/ja01865a069

Reference yield:

4-(1-bromo-propyl)-anisole (536-44-7) → meso-hexestrol dimethyl ether (28231-25-6) + racem.-3,4-bis-(4-methoxy-phenyl)-hexane (130-78-9,28199-75-9,28231-25-6,53584-73-9)

Guidance literature:

With nickel; Petroleum ether; at 75 - 80 ℃; weiteres Reagens: Wasser; unter Abdestillieren des Petrolaethers;

DOI:10.1021/jo01158a010

Reference yield:

→ meso-hexestrol dimethyl ether (28231-25-6) + racem.-3,4-bis-(4-methoxy-phenyl)-hexane (130-78-9,28199-75-9,28231-25-6,53584-73-9)

Guidance literature:

With i-Amyl alcohol; sodium;

DOI:10.1021/ja01211a007

upstream raw materials:

diazomethane

hexestrol

methyl iodide

dimethyl sulfate

Downstream raw materials:

dl-hexestrol

meso-hexestrol dimethyl ether

racem.-3,4-bis-(4-methoxy-3-nitro-phenyl)-hexane

meso-3,3'-difluorohexestrol dimethyl ether

Refernces

• 1、 Peak,Short. "-". . p. 232. Retrieved 1943.
• 2、 Rathore,Weigand,Kochi. "Efficient hydrogenation of sterically hindered olefins with borane-methyl sulfide complex". . p. 5246 - 5256. Retrieved 2007/10/03.
• 3、 Ng,Katzenellenbogen,Kilbourn. "Aromatic fluorinations suitable for fluorine-18 labeling of estrogens". . p. 2520 - 2528. Retrieved 2007/10/02.