Technology Process of 14β-phenylpropyl-17-cyclopropylmethyl-4,5α-epoxy-6-methylenemorphinan-3,14-triol
There total 5 articles about 14β-phenylpropyl-17-cyclopropylmethyl-4,5α-epoxy-6-methylenemorphinan-3,14-triol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
for 1h;
Heating / reflux;
- Guidance literature:
-
14-(3'-phenylpropyl)nalmefene;
With
boron tribromide;
In
dichloromethane;
at -15 ℃;
for 0.25h;
With
ammonia;
In
dichloromethane;
at 0 ℃;
for 0.5h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran / Reflux
2.1: palladium on activated charcoal; hydrogen
3.1: boron tribromide / dichloromethane / 0.25 h / -15 °C
3.2: 0.5 h / 0 °C
With
palladium on activated charcoal; hydrogen; boron tribromide; sodium hydride;
In
tetrahydrofuran; dichloromethane;
