Diphenethylamine

Base Information

• Chemical Name: Diphenethylamine
• CAS No.: 6308-98-1
• Molecular Formula: C16H20N+
• Molecular Weight: 225.334
• Hs Code.: 2921199090
• European Community (EC) Number: 809-341-7
• NSC Number: 41741
• DSSTox Substance ID: DTXSID80979028
• Nikkaji Number: J411.689E
• Wikidata: Q82964539
• Mol file: 6308-98-1.mol

Synonyms:Diphenethylamine;Bis(2-phenylethyl)amine;6308-98-1;Diphenethyl-amine;Benzeneethanamine, N-(2-phenylethyl)-;2-phenyl-N-(2-phenylethyl)ethanamine;N,N-bis(2-phenylethyl)amine hydrochloride;N-diphenethylamine;N,N-Bis(2-phenylethyl)amine;SCHEMBL283735;N,N-Bis(2-phenylethyl)amine #;DTXSID80979028;NSC41741;NSC-41741;WY-507;AKOS000115598;2-Phenyl-N-(2-phenylethyl)ethan-1-amine;CS-0246622;EN300-33453

Chemical Property of Diphenethylamine

Chemical Property:

• Vapor Pressure: 3.61E-05mmHg at 25°C
• Melting Point: 29°C
• Refractive Index: 1.5550
• Boiling Point: 353.3°C at 760 mmHg
• PKA: 9.97±0.19(Predicted)
• Flash Point: 169.5°C
• PSA: 12.03000
• Density: 1.002g/cm³
• LogP: 4.25430
• XLogP3: 3.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 6
• Exact Mass: 225.151749610
• Heavy Atom Count: 17
• Complexity: 158

Purity/Quality:

99% ^*data from raw suppliers

bis(2-phenylethyl)amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CCNCCC2=CC=CC=C2

Technology Process of Diphenethylamine

There total 81 articles about Diphenethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

phenylacetonitrile (140-29-4) + benzylamine (100-46-9) → N-benzyl-2-phenylethylamine (3647-71-0) + diphenethylamine (6308-98-1)

Guidance literature:

With 3 % platinum on carbon; hydrogen; In toluene; at 105 ℃; under 4500.45 Torr; Flow reactor;

DOI:10.1039/c2cy20431b

Reference yield: 74.0%

phenylacetonitrile (140-29-4) → (+)-3-methyl-2-phenylbutylamine (196106-01-1) + phenethylamine (64-04-0) + diphenethylamine (6308-98-1)

Guidance literature:

With sodium tetrahydroborate; hydrogen; nickel dichloride; In isopropyl alcohol; at 70 ℃; for 16h; under 760.051 Torr;

DOI:10.1134/S1070363216020110

Reference yield: 72.0%

phenylacetonitrile (140-29-4) → phenethylamine (64-04-0) + diphenethylamine (6308-98-1)

Guidance literature:

With methanol; cobalt(II) chloride; diborane; at -20 ℃; for 0.5h;

upstream raw materials:

1-(2-phenylethyl)aziridine

benzene

(2-nitroethenyl)benzene

N-phenethyl-2-phenylethanethioamide

Downstream raw materials:

N-phenyl-N-(2-phenylethyl)aniline

N,N-diphenethyl-benzamide

allyl-diphenethyl-amine

N-benzyl-2-phenylethylamine

Refernces

• 1、 Hasegawa, Eietsu,Tosaka, Emi,Yoneoka, Akira,Tamura, Yukinobu,Takizawa, Shin-Ya,Tomura, Masaaki,Yamashita, Yoshiro. "Photoinduced electron-transfer reaction of α-bromomethyl-substituted benzocyclic β-keto esters with amines: Selective reaction pathways depending on the nature of the amine radical cations". . p. 247 - 267. Retrieved 2013.
• 2、 -. "Method for synthesizing dibenzylamine compound by selective hydrogenation of photocatalytic benzonitrile compound". Paragraph 0044-0047. . Retrieved 2021/09/29.
• 3、 Kakiuchi, Fumitoshi,Kochi, Takuya,Morimoto, Yoshihiko. "Rhodium-Catalyzed Anti-Markovnikov Hydroamination of Aliphatic and Aromatic Terminal Alkynes with Aliphatic Primary Amines". . p. 13143 - 13152. Retrieved 2021/09/28.