Technology Process of 5-(tert-butoxycarbonylamino)-1-(phenylsulfonyl)-1H-indole-2-carboxylic acid
There total 7 articles about 5-(tert-butoxycarbonylamino)-1-(phenylsulfonyl)-1H-indole-2-carboxylic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
tert-butyl (1-(phenylsulfonyl)-1H-indol-5-yl)carbamate;
With
tert.-butyl lithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 1h;
Inert atmosphere;
carbon dioxide;
In
tetrahydrofuran; hexane;
at -78 - 20 ℃;
Inert atmosphere;
With
hydrogenchloride;
In
water;
DOI:10.1016/j.bmcl.2011.09.001
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: dmap; triethylamine / dichloromethane / 20 °C
2.1: nitric acid / nitromethane / 1 h / 0 °C
3.1: manganese(IV) oxide / dichloromethane / 24 h / Molecular sieve; Reflux
4.1: tin(II) chloride dihdyrate / ethanol / 2 h / Reflux
5.1: tetrahydrofuran / 16 h / 20 °C
6.1: tert.-butyl lithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere
6.2: -78 - 20 °C / Inert atmosphere
With
dmap; manganese(IV) oxide; tin(II) chloride dihdyrate; tert.-butyl lithium; nitric acid; triethylamine;
In
tetrahydrofuran; nitromethane; ethanol; hexane; dichloromethane;
DOI:10.1016/j.bmcl.2011.09.001
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: nitric acid / nitromethane / 1 h / 0 °C
2.1: manganese(IV) oxide / dichloromethane / 24 h / Molecular sieve; Reflux
3.1: tin(II) chloride dihdyrate / ethanol / 2 h / Reflux
4.1: tetrahydrofuran / 16 h / 20 °C
5.1: tert.-butyl lithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere
5.2: -78 - 20 °C / Inert atmosphere
With
manganese(IV) oxide; tin(II) chloride dihdyrate; tert.-butyl lithium; nitric acid;
In
tetrahydrofuran; nitromethane; ethanol; hexane; dichloromethane;
DOI:10.1016/j.bmcl.2011.09.001
