diflunisal glucuronide ester

Base Information

• Chemical Name: diflunisal glucuronide ester
• CAS No.: 58446-30-3
• Molecular Formula: C₁₉H₁₆F₂O₉
• Molecular Weight: 426.327
• Mol file: 58446-30-3.mol

Synonyms:Diflunisalacyl glucuronide

Chemical Property of diflunisal glucuronide ester

Chemical Property:

• Boiling Point: 653°Cat760mmHg
• PKA: 2.58±0.70(Predicted)
• Flash Point: 348.7°C
• PSA: 153.75000
• Density: 1.7g/cm³
• LogP: 0.38640

Purity/Quality:

HPLC ≥ 98% ^*data from raw suppliers

DiflunisalAcyl-β-D-glucuronide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Diflunisal Acyl-β-D-glucuronide is used in the inhibition of proliferation of HT-29 colon adenocarcinoma cells by carboxylate NSAIDs and their acyl glucuronides.

Technology Process of diflunisal glucuronide ester

There total 1 articles about diflunisal glucuronide ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2',4'-difluoro-4-hydroxybiphenyl-3-carboxylic acid (22494-42-4) + UDP-glucuronic acid (2616-64-0) → Diflunisal acyl glucuronide (58446-30-3) + Diflunisal phenolic glucuronide

Guidance literature:

With sacharic acid 1,4-lactone; rat liver microsomes; magnesium chloride; In phosphate buffer; at 37 ℃; for 0.25h; pH=6.5; Further Variations:; Reagents; Enzyme kinetics;

DOI:10.3109/00498259609046694

upstream raw materials:

2',4'-difluoro-4-hydroxybiphenyl-3-carboxylic acid

UDP-glucuronic acid

Refernces