(+)-Normetazocine

Base Information

• Chemical Name: (+)-Normetazocine
• CAS No.: 25144-78-9
• Molecular Formula: C₁₄H₁₉NO
• Molecular Weight: 217.311
• European Community (EC) Number: 246-653-7
• DSSTox Substance ID: DTXSID70453044
• Nikkaji Number: J257.405E
• Wikidata: Q82274021
• Mol file: 25144-78-9.mol

Synonyms:(+)-Normetazocine;dl-Normetazocine;16670-83-0;(1S,9S,13S)-1,13-dimethyl-10-azatricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-4-ol;25144-78-9;SCHEMBL13589886;DTXSID70453044

Chemical Property of (+)-Normetazocine

Chemical Property:

• Boiling Point: 355.8°Cat760mmHg
• PKA: 9.79±0.60(Predicted)
• Flash Point: 128°C
• PSA: 32.26000
• Density: g/cm³
• LogP: 2.53280
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 217.146664230
• Heavy Atom Count: 16
• Complexity: 280

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s): A poison.
• Hazard Codes: A poison.

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1C2CC3=C(C1(CCN2)C)C=C(C=C3)O
• Isomeric SMILES: C[C@@H]1[C@@H]2CC3=C([C@]1(CCN2)C)C=C(C=C3)O
• Uses: Antagonistic and analgetic activities. Precursor for the preparation of (+/-)-Pentazocine, (+/-)-Cyclazocine

Technology Process of (+)-Normetazocine

There total 5 articles about (+)-Normetazocine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 8-Hydroxy-2,6-methano-6α,11α-dimethyl-1,2,3,4,5,6-hexahydro-3-benzazocin (16603-67-1,16670-83-0,16670-84-1,16670-86-3,16671-00-4,16808-63-2,25144-77-8,25144-78-9,52079-30-8)

Guidance literature:

3-Benzyl-8-hydroxy-2,6-methano-6α,11α-dimethyl-1,2,3,4,5,6-hexahydro-3-benzazocin-hydrochlorid, H2, Pd/C;

Reference yield:

→ 6,11syn-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benz[d]azocin-8-ol (16603-67-1,16670-83-0,16670-84-1,16670-86-3,16671-00-4,16808-63-2,25144-77-8,25144-78-9,52079-30-8)

Guidance literature:

With acetic anhydride; Erwaermen des Reaktionsprodukts mit Bromcyan in Chloroform und Erhitzen des nach dem Eindampfen erhaltenen Rueckstandes mit wss. Salzsaeure_.;

DOI:10.1021/jo01083a609

Reference yield:

→ 2'-Hydroxy-5,9α-dimethyl-6,7-benzomorphan (16603-67-1,16670-83-0,16670-84-1,16670-86-3,16671-00-4,16808-63-2,25144-77-8,25144-78-9,52079-30-8)

Guidance literature:

Methoxyverb. (6), HBr;

DOI:10.1248/cpb.25.1106

Downstream raw materials:

(-)-Pentazocine

3-benzyl-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-ol; hydrobromide

(-)-N-Allyl-N-normetazocine

(-)-Cyclazocine

Refernces