(+)-(2R,2'R,2''R)-triphenylethan-2-olamine

Base Information

• Chemical Name: (+)-(2R,2'R,2''R)-triphenylethan-2-olamine
• CAS No.: 156317-12-3
• Molecular Formula: C₂₄H₂₇NO₃
• Molecular Weight: 377.483
• Mol file: 156317-12-3.mol

Synonyms:(+)-(2R,2'R,2''R)-triphenylethan-2-olamine

Chemical Property of (+)-(2R,2'R,2''R)-triphenylethan-2-olamine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (+)-(2R,2'R,2''R)-triphenylethan-2-olamine

There total 2 articles about (+)-(2R,2'R,2''R)-triphenylethan-2-olamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

(R)-Styrene oxide (20780-53-4) → (+)-(2R,2'R,2''R)-triphenylethan-2-olamine (156317-12-3)

Guidance literature:

With methanol; ammonia; at 60 ℃; for 120h;

DOI:10.1021/ja00093a011

Reference yield:

(R)-Styrene oxide (20780-53-4) + (R)-2-Amino-1-phenylethanol (2549-14-6,1936-63-6) → (+)-(2R,2'R,2''R)-triphenylethan-2-olamine (156317-12-3) + (R,R)-bis(2-phenylethan-2-ol)-(S)-(1-phenyl-2-ethanol)amine

Guidance literature:

In methanol; at 130 ℃; for 0.583333h; under 3750.3 Torr; microwave irradiation;

DOI:10.1016/S0040-4039(02)00306-4

Reference yield: 80.0%

Cp*TiCl3 (12129-06-5) + (+)-(2R,2'R,2''R)-triphenylethan-2-olamine (156317-12-3) → (pentamethylcyclopentadienyl)titanium(tris((R)-phenylethanolate)amine)

Guidance literature:

With triethylamine; In dichloromethane; under Ar, standard Schlenk techniques; soln. of Ti complex in CH2Cl2 added dropwise to stirred soln. of ligand and Et3N (molar ratio 1:1:3) in CH2Cl2 at -78°C; warmed to room temp.; stirred for 12 h; solvent removed under vac.; redissolved in toluene; filtered through Celite; solvent removed from filtrate; elem. anal.;

DOI:10.1016/S0022-328X(02)01555-3

upstream raw materials:

(R)-Styrene oxide

(R)-2-Amino-1-phenylethanol

Downstream raw materials:

((C₅H₄N)(C₅H₃N)CO₂CH(C₆H₅)CH₂)3N

Refernces

• 1、 Favretto, Laura,Nugent, William A.,Licini, Giulia. "Highly regioselective microwave-assisted synthesis of enantiopure C3-symmetric trialkanolamines". . p. 2581 - 2584. Retrieved 2002.