Benzyloxycarbonyl-O-methyl-threonin

Base Information

• Chemical Name: Benzyloxycarbonyl-O-methyl-threonin
• CAS No.: 70561-63-6
• Molecular Formula: C₁₃H₁₇NO₅
• Molecular Weight: 267.282
• Mol file: 70561-63-6.mol

Synonyms:Benzyloxycarbonyl-O-methyl-threonin

Chemical Property of Benzyloxycarbonyl-O-methyl-threonin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzyloxycarbonyl-O-methyl-threonin

There total 2 articles about Benzyloxycarbonyl-O-methyl-threonin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl (2S,3R)-2-(benzyloxycarbonylamino)-3-hydroxybutyrate (57224-63-2) → Benzyloxycarbonyl-O-methyl-threonin (70561-63-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / Ag₂O / acetone

2: aq. LiOH / tetrahydrofuran

With lithium hydroxide; silver(l) oxide; In tetrahydrofuran; acetone;

DOI:10.1016/j.bmcl.2004.12.082

Reference yield:

methyl (2S,3R)-2-(benzyloxycarbonylamino)-3-hydroxybutyrate (57224-63-2) + methyl iodide (74-88-4) → Benzyloxycarbonyl-O-methyl-threonin (70561-63-6)

Guidance literature:

Multistep reaction; (i) Ag₂O, acetone, (ii) aq. NaOH;

Reference yield:

Benzyloxycarbonyl-O-methyl-threonin (70561-63-6) → O-methyl-L-threonine (4144-02-9)

Guidance literature:

With hydrogen; Pd-BaSO₄;

DOI:10.1016/j.bmcl.2004.12.082

upstream raw materials:

methyl (2S,3R)-2-(benzyloxycarbonylamino)-3-hydroxybutyrate

methyl iodide

Downstream raw materials:

O-methyl-L-threonine

Refernces