phenacyl phenyl sulfide

Base Information

• Chemical Name: phenacyl phenyl sulfide
• CAS No.: 16222-10-9
• Molecular Formula: C14H12 O S
• Molecular Weight: 228.315
• Hs Code.: 2930909090
• Mol file: 16222-10-9.mol

Synonyms:Acetophenone,2-(phenylthio)- (6CI,7CI,8CI); 1-Phenyl-2-(phenylthio)ethanone;2-(Phenylthio)acetophenone; Benzoylmethyl phenyl sulfide; NSC 608609; Phenacylphenyl sulfide; Phenyl phenacyl sulfide; Phenyl phenylthiomethyl ketone; a-(Phenylthio)acetophenone; w-(Phenylthio)acetophenone

Chemical Property of phenacyl phenyl sulfide

Chemical Property:

• Vapor Pressure: 1.39E-05mmHg at 25°C
• Boiling Point: 367.1°Cat760mmHg
• Flash Point: 195.7°C
• PSA: 42.37000
• Density: 1.17g/cm³
• LogP: 3.66160

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of phenacyl phenyl sulfide

There total 93 articles about phenacyl phenyl sulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.3%

thiophenol (108-98-5) + α-bromoacetophenone (70-11-1) → 1-phenyl-2-(phenylthio)ethanone (16222-10-9)

Guidance literature:

With sodium hydroxide; In sulfolane; methanol; for 0.25h; Ambient temperature;

DOI:10.1021/ja00254a038

Reference yield: 95.0%

α-bromoacetophenone (70-11-1) + diphenyldisulfane (882-33-7) → 1-phenyl-2-(phenylthio)ethanone (16222-10-9)

Guidance literature:

With borohydride exchange resin; In methanol; 1.) reflux, 1 h, 2.) r.t., 1 h;

DOI:10.1021/jo00091a047

Reference yield: 95.0%

thiophenol (108-98-5) + 1-chloroacetophenone (532-27-4,108321-66-0,164322-25-2) → 1-phenyl-2-(phenylthio)ethanone (16222-10-9)

Guidance literature:

With potassium carbonate; Aliquat 336; In toluene; at 20 ℃; for 2h;

upstream raw materials:

2-diazo-acetophenone

thiophenol

1-chloroacetophenone

sodium thiophenolate

Downstream raw materials:

ω,ω-bis(phenylthio)acetophenone

5-Oxo-5-phenyl-4-phenylsulfanyl-pentanoic acid methyl ester

[(1-phenylethyl)thio]benzene

(S)-(-)-(2-hydroxy-2-phenyl-1-ethyl)-phenyl thioether

Refernces

• 1、 Agawa, Toshio,Ishikawa, Minori,Komatsu, Mitsuo,Ohshiro, Yoshiki. "Chemical Property of 1-Dialkylamino-2-phenylthioethylene". . p. 1679 - 1680. Retrieved 1982.
• 2、 Schulz, Robert,Atef, Amira,Becker, Daniel,Gottschalk, Franziska,Tauber, Carolin,Wagner, Stefan,Arkona, Christoph,Abdel-Hafez, Atef A.,Farag, Hassan H.,Rademann, J?rg,Wolber, Gerhard. "Phenylthiomethyl Ketone-Based Fragments Show Selective and Irreversible Inhibition of Enteroviral 3C Proteases". . p. 1218 - 1230. Retrieved 2018.
• 3、 Lyu, Zhigang,Zhao, Yue,Buuh, Zakey Yusuf,Gorman, Nicole,Goldman, Aaron R.,Islam, Md Shafiqul,Tang, Hsin-Yao,Wang, Rongsheng E.. "Steric-Free Bioorthogonal Labeling of Acetylation Substrates Based on a Fluorine-Thiol Displacement Reaction". supporting information. p. 1341 - 1347. Retrieved 2021/02/01.
• 4、 Yang, Lei,Zhou, Shun,Zhao, Jian-Qiang,You, Yong,Wang, Zhen-Hua,Zhou, Ming-Qiang,Yuan, Wei-Cheng. "A cascade deprotonation/intramolecular aldol reaction of α-carbonyl sulfonium ylides with 2-mercaptoindole-3-carbaldehydes and 2-mercaptobenzaldehydes to access thieno[2,3-b]indoles and benzothiophenes". supporting information. p. 3678 - 3686. Retrieved 2021/05/05.