Technology Process of (S)-5-fluoro-2-(4-methoxyphenyl)-2,3-dihydrobenzofuran
There total 3 articles about (S)-5-fluoro-2-(4-methoxyphenyl)-2,3-dihydrobenzofuran which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
[bis(2-methylallyl)cycloocta-1,5-diene]ruthenium(II); 1,3-bis((R)-1-(naphthalen-1-yl)ethyl)-4,5-dihydro-1H-imidazol-3-ium tetrafluoroborate; potassium tert-butylate; hydrogen;
In
hexane;
at 40 ℃;
for 16h;
under 45004.5 Torr;
optical yield given as %ee;
enantioselective reaction;
Inert atmosphere;
Autoclave;
DOI:10.1016/j.tet.2012.03.109
- Guidance literature:
-
Multi-step reaction with 2 steps
1: tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; cesium fluoride; bis[2-(diphenylphosphino)phenyl] ether / 1,4-dioxane / 100 °C / Inert atmosphere
2: [bis(2-methylallyl)cycloocta-1,5-diene]ruthenium(II); 1,3-bis((R)-1-(naphthalen-1-yl)ethyl)-4,5-dihydro-1H-imidazol-3-ium tetrafluoroborate; potassium tert-butylate; hydrogen / hexane / 16 h / 40 °C / 45004.5 Torr / Inert atmosphere; Autoclave
With
[bis(2-methylallyl)cycloocta-1,5-diene]ruthenium(II); tris-(dibenzylideneacetone)dipalladium(0); 1,3-bis((R)-1-(naphthalen-1-yl)ethyl)-4,5-dihydro-1H-imidazol-3-ium tetrafluoroborate; potassium tert-butylate; hydrogen; caesium carbonate; cesium fluoride; bis[2-(diphenylphosphino)phenyl] ether;
In
1,4-dioxane; hexane;
DOI:10.1016/j.tet.2012.03.109
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 60 °C / Inert atmosphere
1.2: 60 - 70 °C / Inert atmosphere
2.1: tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; cesium fluoride; bis[2-(diphenylphosphino)phenyl] ether / 1,4-dioxane / 100 °C / Inert atmosphere
3.1: [bis(2-methylallyl)cycloocta-1,5-diene]ruthenium(II); 1,3-bis((R)-1-(naphthalen-1-yl)ethyl)-4,5-dihydro-1H-imidazol-3-ium tetrafluoroborate; potassium tert-butylate; hydrogen / hexane / 16 h / 40 °C / 45004.5 Torr / Inert atmosphere; Autoclave
With
[bis(2-methylallyl)cycloocta-1,5-diene]ruthenium(II); tris-(dibenzylideneacetone)dipalladium(0); 1,3-bis((R)-1-(naphthalen-1-yl)ethyl)-4,5-dihydro-1H-imidazol-3-ium tetrafluoroborate; potassium tert-butylate; hydrogen; potassium carbonate; caesium carbonate; cesium fluoride; bis[2-(diphenylphosphino)phenyl] ether;
In
1,4-dioxane; hexane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2012.03.109