Sulfaguanidine

Base Information

• Chemical Name: Sulfaguanidine
• CAS No.: 57-67-0
• Deprecated CAS: 61116-95-8,2680613-78-7
• Molecular Formula: C7H10N4O2S
• Molecular Weight: 214.248
• Hs Code.: 2935.00
• European Community (EC) Number: 200-345-9
• NSC Number: 757861,14041
• UNII: 15XQ8043FN
• DSSTox Substance ID: DTXSID1023609
• Nikkaji Number: J2.328K
• Wikipedia: Sulfaguanidine
• Wikidata: Q414886
• NCI Thesaurus Code: C76977
• Pharos Ligand ID: SZ4P7QT5YDRS
• Metabolomics Workbench ID: 71478
• ChEMBL ID: CHEMBL338802
• Mol file: 57-67-0.mol

Synonyms:Gastro Entericanis Biocanina;Gastro-Entericanis Biocanina;GastroEntericanis Biocanina;Sulfaguanidine;Sulphaguanidine;Veto centre;Veto-centre

Chemical Property of Sulfaguanidine

Chemical Property:

• Appearance/Colour: white powder
• Vapor Pressure: 1.09E-09mmHg at 25°C
• Melting Point: 190-193 °C
• Refractive Index: 1.695
• Boiling Point: 488.4 °C at 760 mmHg
• PKA: pKa 2.37(H2O t = 37) (Uncertain)
• Flash Point: 249.2 °C
• PSA: 130.44000
• Density: 1.62 g/cm³
• LogP: 2.29350
• Storage Temp.: -20°C
• Solubility.: 1 M HCl: soluble50mg/mL
• Water Solubility.: 1g/1000mL at 25 ºC
• XLogP3: -0.7
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 214.05244675
• Heavy Atom Count: 14
• Complexity: 307

Purity/Quality:

99.5% ^*data from raw suppliers

Sulfaguanidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC(=CC=C1N)S(=O)(=O)N=C(N)N
• Uses: 1. It belongs to sulfa drugs and used for the treatment of bacillary dysentery and enteritis. 2. It can be used for the treatment of intestinal antibacterial infections such as bacterial dysentery enteritis and can also be used to prevent infection before bowel surgery. 3. It is the first-choice of drug for the treatment of leprosy, being suitable for the treatment of various types of leprosy and being able to alleviate the clinical symptoms. It can generally alleviate the mucosal lesions rapidly with the improvement of skin lesions occurring more slowly, with even slower rate in neuropathy, thereby leading to long course. It is easy to produce drug resistance and difficult to cure. In addition, it can also be used for the treatment of dermatitis herpetiformis, lupus, psoriasis, foot fungus disease and malaria. Its preparation is tablet. Sulfonamide antibacterial. Sulfaguanidine is a sulfonamide based antibiotic drug with potential application in veterinary medicine.
• Therapeutic Function: Antimicrobial

Technology Process of Sulfaguanidine

There total 19 articles about Sulfaguanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.1%

guanidine hydrochloride (50-01-1) + sulfanilamide (63-74-1) → 4-amino-N-(diaminomethylene) benzenesulfonamide (57-67-0)

Guidance literature:

With potassium iodide; In water; at 65 ℃; for 3h; Temperature; Reagent/catalyst; Large scale;

Reference yield: 13.2%

4-nitro-N-(1-azidoformimidoyl)benzenesulfonamide → 1-amino-4-({[amino(imino)methyl]amino}sulfonyl)benzene (57-67-0,61116-95-8)

Guidance literature:

With sodium tetrahydroborate; nickel(II) chloride hexahydrate; In tetrahydrofuran; methanol; at 0 ℃;

DOI:10.1016/j.bmc.2010.06.038

Reference yield:

dicyandiamide (127099-85-8,780722-26-1) + sulfanilamide (63-74-1) → 1-amino-4-({[amino(imino)methyl]amino}sulfonyl)benzene (57-67-0,61116-95-8)

Guidance literature:

With ammonium carbonate; sodium carbonate; pyrographite; ammonium chloride; at 150 ℃; for 30h; Temperature;

upstream raw materials:

N-(4-{[(aminoiminomethyl)amino]sulfonyl}phenyl)acetamide

S-ethyl-N-sulfanilyl-isothiourea

sulfanilylcarbamimidoyl-urea

guanidine nitrate

Downstream raw materials:

sulfanilic acid-(4-methyl-6-oxo-1,6-dihydro-pyrimidin-2-ylamide)

N-(4-carbamimidoylsulfamoyl-phenyl)-phthalamic acid

[N-(5-nitro-furfurylidene)-sulfanilyl]-guanidine

[4-(2-methyl-4-oxo-4H-quinazolin-3-yl)-benzenesulfonyl]-guanidine

Refernces

• 1、 Sroor, Farid M.,Othman, Abdelmageed M.,Tantawy, Mohamed A.,Mahrous, Karima F.,El-Naggar, Mostafa E.. "Synthesis, antimicrobial, anti-cancer and in silico studies of new urea derivatives". . . Retrieved 2021/05/10.
• 2、 -. "Method for synthesizing sulphaguanidine". Paragraph 0017; 0018. . Retrieved 2016/10/31.