2-(ACETYLAMINO)-3,3-DIMETHYLBUTANOIC ACID

Base Information

• Chemical Name: 2-(ACETYLAMINO)-3,3-DIMETHYLBUTANOIC ACID
• CAS No.: 22146-58-3
• Molecular Formula: C₈H₁₅NO₃
• Molecular Weight: 173.212
• Hs Code.: 2924297099
• Mol file: 22146-58-3.mol

Synonyms:(+/-)-2-acetylamino-3,3-dimethylbutyric acid

Chemical Property of 2-(ACETYLAMINO)-3,3-DIMETHYLBUTANOIC ACID

Chemical Property:

Purity/Quality:

2-Acetamido-3,3-dimethylbutanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(ACETYLAMINO)-3,3-DIMETHYLBUTANOIC ACID

There total 6 articles about 2-(ACETYLAMINO)-3,3-DIMETHYLBUTANOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.2%

2-amino-3,3-dimethylbutanoic acid (33105-81-6) + acetic anhydride (108-24-7) → (+/-)-2-acetylamino-3,3-dimethylbutyric acid (22146-58-3,3120-64-7)

Guidance literature:

With sodium hydroxide; In water; for 3h;

DOI:10.1271/bbb.65.1977

Reference yield: 55.0%

acetamide (60-35-5) + carbon monoxide (201230-82-2) + pivalaldehyde (630-19-3) → (+/-)-2-acetylamino-3,3-dimethylbutyric acid (22146-58-3,3120-64-7)

Guidance literature:

With polymer incarcerated Pd(PPh₃)4; sulfuric acid; benzyltriethylammonium bromide; In 1,4-dioxane; at 120 ℃; for 15h; under 45600 Torr;

DOI:10.1016/j.jorganchem.2004.07.017

Reference yield:

2-amino-3,3-dimethylbutanoic acid (33105-81-6) + acetyl chloride (75-36-5) → (+/-)-2-acetylamino-3,3-dimethylbutyric acid (22146-58-3,3120-64-7)

Guidance literature:

With sodium hydroxide; In water; at 0 ℃; pH=10;

upstream raw materials:

2-amino-3,3-dimethylbutanoic acid

acetic anhydride

N-(2,2-dimethyl-1-phenylpropyl)acetamide

acetamide

Downstream raw materials:

2-(benzoylamino)-3,3-dimethylbutanoic acid

(Z)-N-(1-(4-(4-hydroxybenzylidene)-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-2-yl)-2,2-dimethylpropyl)acetamide

L-tert-Leucine

D-tert-leucine

Refernces

• 1、 Li, Jiacheng,Siang Tan, Suan,Kyne, Sara Helen,Wai Hong Chan, Philip. "Minisci-Type Alkylation of N-Heteroarenes by N-(Acyloxy)phthalimide Esters Mediated by a Hantzsch Ester and Blue LED Light". supporting information. p. 802 - 810. Retrieved 2022/01/11.
• 2、 Akiyama, Ryo,Sagae, Takahiro,Sugiura, Masaharu,Kobayashi, Shu. "Efficient synthesis of N-acyl-α-amino acids via polymer incarcerated palladium-catalyzed amidocarbonylation". . p. 3806 - 3809. Retrieved 2007/10/03.