Irsogladine maleate

Base Information

• Chemical Name: Irsogladine maleate
• CAS No.: 84504-69-8
• Molecular Formula: C9H7Cl2N5^.C4H4O4
• Molecular Weight: 372.167
• Hs Code.: 2933699090
• European Community (EC) Number: 692-440-0
• UNII: 66GVU60EPQ
• DSSTox Substance ID: DTXSID2040234
• Wikidata: Q27263995
• ChEMBL ID: CHEMBL1712923
• Mol file: 84504-69-8.mol

Synonyms:2,4-diamino-6-(2,5-dichlorophenyl)-s-triazine maleate;6-(2,5-dichlorophenyl)-2,4-diamino-1,3,5-triazine;DCPDAT;irsogladine;irsogladine maleate;MN 1695;MN-1695

Chemical Property of Irsogladine maleate

Chemical Property:

• Vapor Pressure: 3.07E-12mmHg at 25°C
• Melting Point: 181-182 °C
• Boiling Point: 552.2oC at 760 mmHg
• Flash Point: 287.8oC
• PSA: 165.31000
• LogP: 2.88400
• Storage Temp.: Desiccate at RT
• Water Solubility.: Insoluble in water
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 3
• Exact Mass: 371.0188092
• Heavy Atom Count: 24
• Complexity: 351

Purity/Quality:

99% ^*data from raw suppliers

Irsogladine Maleate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1Cl)C2=NC(=NC(=N2)N)N)Cl.C(=CC(=O)O)C(=O)O
• Isomeric SMILES: C1=CC(=C(C=C1Cl)C2=NC(=NC(=N2)N)N)Cl.C(=C\C(=O)O)\C(=O)O
• Recent ClinicalTrials: Therapeutic Effect of Isogladine Maleate on Small Intestinal Mucosal Injury Associated With NSAIDS in Population
• Recent NIPH Clinical Trials: Irsogladine maleate and rabeprazole in non-erosive reflux disease - a double-blind, placebo- controlled study
• Description: Irsogladine is a gastroprotective agent. It increases transfer of Lucifer yellow CH between isolated rabbit gastric epithelial cells, indicating enhanced gap junction intercellular communication (GJIC). Irsogladine (3 mg/kg) inhibits gastric mucosal lesion formation and decreases in gastric mucosal blood flow induced by monochloramine in rats, effects that can be prevented by the nitric oxide synthase inhibitor L-NAME . It also inhibits superoxide anion production induced by fMLP and increases cAMP levels in isolated human neutrophils in a concentration-dependent manner, similar to the phosphodiesterase 4 (PDE4) inhibitor rolipram .
• Uses: An anti-ulcer drug. antiulcerative;selective PDE4 inhibitor which also enhances gap junction intercellular communication

Technology Process of Irsogladine maleate

There total 1 articles about Irsogladine maleate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.8%

maleic acid (110-16-7,26099-09-2) + irsogladine (57381-26-7) → irsogladine maleate (84504-69-8)

Guidance literature:

With glycerol formal; at 45 - 50 ℃; for 0.5h; Concentration;

Reference yield: 70.0%

irsogladine maleate (84504-69-8) → irsogladine (57381-26-7)

Guidance literature:

With sodium hydrogencarbonate; In ethyl acetate; at 20 ℃; for 1h;

DOI:10.1002/bkcs.10291

upstream raw materials:

maleic acid

irsogladine

Downstream raw materials:

irsogladine

Refernces

• 1、 -. "Preparation method for irsogladine maleate". Paragraph 0016; 0019; 0022; 0025. . Retrieved 2017/04/29.