3,5-Difluorobenzoyl chloride

Base Information

• Chemical Name: 3,5-Difluorobenzoyl chloride
• CAS No.: 129714-97-2
• Molecular Formula: C7H3 Cl F2 O
• Molecular Weight: 176.55
• Hs Code.: 2916399090
• Mol file: 129714-97-2.mol

Synonyms:3,5-Difluorobenzenecarbonylchloride; 3,5-Difluorobenzoyl chloride

Chemical Property of 3,5-Difluorobenzoyl chloride

Chemical Property:

• Appearance/Colour: clear light yellow liquid
• Vapor Pressure: 0.67mmHg at 25°C
• Refractive Index: n20/D 1.5031(lit.)
• Boiling Point: 173-175°C
• Flash Point: 69 ºC
• PSA: 17.07000
• Density: 1.5
• LogP: 2.34380
• Sensitive.: Moisture Sensitive
• Water Solubility.: It reacts with water.

Purity/Quality:

99.5% ^*data from raw suppliers

3,5-Difluorobenzoyl Chloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C
• Statements: 34-36/37
• Safety Statements: 23-26-27-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 3,5-Difluorobenzoyl chloride, is used as an pharmaceutical intermediate, organic intermediate and chemical synthesis.

Technology Process of 3,5-Difluorobenzoyl chloride

There total 3 articles about 3,5-Difluorobenzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3,5-difluorobenzoic acid (455-40-3) → 3,5-difluorobenzoyl chloride (129714-97-2)

Guidance literature:

With thionyl chloride; for 5h; Reflux;

Reference yield:

1,3-difluoro-5-iodobenzene (2265-91-0) → 3,5-difluorobenzoyl chloride (129714-97-2)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; at 100 ℃; for 12h;

DOI:10.1038/s41557-018-0078-8

Reference yield:

→ 3,5-difluorobenzoyl chloride (129714-97-2)

Guidance literature:

upstream raw materials:

3,5-difluorobenzoic acid

1,3-difluoro-5-iodobenzene

Downstream raw materials:

2-(3,5-Difluoro-benzoylamino)-pentanedioic acid

(+/-)-6-methyl-6-azabicyclo<3.2.1>octan-3β-ol 3,5-difluorobenzoate

(+/-)-6-methyl-6-azabicyclo<3.2.1>octan-3α-ol 3,5-difluorobenzoate difuorobenzoate salt

3,5-difluorobenzamide

Refernces

• 1、 Bruder, Marjorie,Cordeiro, Artur T.,Do Nascimento Faria, Jessica,Eufrásio, Amanda G.,Fagundes, Michelle,Mercaldi, Gustavo F.,Mota, Sabrina G. R.,Ranzani, Americo T.. "Trypanosoma cruzi Malic Enzyme Is the Target for Sulfonamide Hits from the GSK Chagas Box". . p. 2455 - 2471. Retrieved 2021/08/06.
• 2、 Cui, Xin-Feng,Hu, Fang-Peng,Huang, Guo-Sheng,Lu, Guo-Qiang. "Base-promoted Lewis acid catalyzed synthesis of quinazoline derivatives". supporting information. p. 4376 - 4380. Retrieved 2020/10/20.