N-butyl-N-(phenylsulfonyl)methacrylamide

Base Information

• Chemical Name: N-butyl-N-(phenylsulfonyl)methacrylamide
• CAS No.: 1197341-61-9
• Molecular Formula: C₁₄H₁₉NO₃S
• Molecular Weight: 281.376
• Mol file: 1197341-61-9.mol

Synonyms:N-butyl-N-(phenylsulfonyl)methacrylamide

Chemical Property of N-butyl-N-(phenylsulfonyl)methacrylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-butyl-N-(phenylsulfonyl)methacrylamide

There total 3 articles about N-butyl-N-(phenylsulfonyl)methacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

C14H20BrNO3S (1197341-38-0) → N-butyl-N-(phenylsulfonyl)methacrylamide (1197341-61-9)

Guidance literature:

With N,N'-dimethylpiperazine; at 65 ℃; for 24h;

DOI:10.1016/j.tetlet.2009.08.125

Reference yield:

N-butylbenzenesulfonamide (3622-84-2) + Methacryloyl chloride (920-46-7,26937-45-1) → N-butyl-N-(phenylsulfonyl)methacrylamide (1197341-61-9)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere; Schlenk technique;

DOI:10.1039/c4ob01231c

Reference yield:

benzenesulfonyl chloride (98-09-9) → N-butyl-N-(phenylsulfonyl)methacrylamide (1197341-61-9)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0 °C / Sealed tube

2: triethylamine; dmap / dichloromethane / 20 °C / Sealed tube

With dmap; triethylamine; In dichloromethane;

DOI:10.1055/s-0034-1378947

upstream raw materials:

C₁₄H₂₀BrNO₃S

N-butylbenzenesulfonamide

Methacryloyl chloride

benzenesulfonyl chloride

Downstream raw materials:

1-butyl-3-methyl-3-(tosylmethyl)indolin-2-one

Refernces

• 1、 Tian, Qingshan,He, Ping,Kuang, Chunxiang. "Copper-catalyzed arylsulfonylation of N-arylsulfonyl-acrylamides with arylsulfonohydrazides: Synthesis of sulfonated oxindoles". supporting information. p. 6349 - 6353. Retrieved 2014/08/18.