Loxapine

Base Information

• Chemical Name: Loxapine
• CAS No.: 1977-10-2
• Molecular Formula: C18H18 Cl N3 O
• Molecular Weight: 327.813
• European Community (EC) Number: 217-835-3
• UNII: LER583670J
• DSSTox Substance ID: DTXSID7023229
• Nikkaji Number: J22.645I
• Wikipedia: Loxapine
• Wikidata: Q58614
• NCI Thesaurus Code: C61816
• RXCUI: 6475
• Pharos Ligand ID: 373GQ7VBYVHW
• Metabolomics Workbench ID: 42769
• ChEMBL ID: CHEMBL831
• Mol file: 1977-10-2.mol

Synonyms:2-Chloro-11-(4-methyl-1-piperazinyl)-dibenz(b,f)(1,4)oxazepine;CL 71,563;CL-71,563;CL71,563;Cloxazepine;Hydrochloride, Loxapine;Loxapine;Loxapine Hydrochloride;Loxapine Monohydrochloride;Loxapine Succinate;Loxapinsuccinate;Loxipine Maleate;Loxipine Succinate;Loxitane;Maleate, Loxipine;Oxilapine;Succinate, Loxapine

Chemical Property of Loxapine

Chemical Property:

• Vapor Pressure: 1.36E-08mmHg at 25°C
• Melting Point: 109-110°
• Refractive Index: 1.5800 (estimate)
• Boiling Point: 458.6°Cat760mmHg
• Flash Point: 231.1°C
• PSA: 28.07000
• Density: 1.31g/cm³
• LogP: 3.08280
• Solubility.: Soluble in DMSO
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 327.1138399
• Heavy Atom Count: 23
• Complexity: 450

Purity/Quality:

99.9% ^*data from raw suppliers

Loxapine >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Drug Classes: Antipsychotic Agents
• Canonical SMILES: CN1CCN(CC1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl
• Recent ClinicalTrials: Tolerability and Analgesic Efficacy of Loxapine in Patients With Refractory, Chemotherapy-induced Neuropathic Pain
• Recent EU Clinical Trials: Prospective naturalistic clinical trail with loxapine in agitated patients with personality disorder
• Uses: Tranquilizer (minor).
• Therapeutic Function: Tranquilizer

Technology Process of Loxapine

There total 3 articles about Loxapine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methanol (67-56-1) + amoxapine (14028-44-5) → loxapine (1977-10-2)

Guidance literature:

With aluminum (III) chloride; water; In acetonitrile; at 20 ℃; Irradiation;

DOI:10.1002/cssc.202002459

Reference yield:

1-methyl-piperazine (109-01-3) + 2,11-dichloro-dibenzo[b,f][1,4]oxazepine (3455-14-9) → loxapine (1977-10-2)

Guidance literature:

In xylene; for 5h; Heating;

DOI:10.1002/hlca.19670500131

Reference yield:

→ loxapine (1977-10-2)

Guidance literature:

entspr. cycl. Amid, Amin;

upstream raw materials:

1-methyl-piperazine

2,11-dichloro-dibenzo[b,f][1,4]oxazepine

methanol

amoxapine

Downstream raw materials:

2-chlorodibenzo[b,f][1,4]oxazepin-11(10H)-one

2,11-dichloro-dibenzo[b,f][1,4]oxazepine

amoxapine

Refernces

• 1、 Han, Xingyou,Li, Feng,Liu, Peng,Meng, Chong,Tung, Nguyen Thanh. "N-Methylation of Amines with Methanol in Aqueous Solution Catalyzed by a Water-Soluble Metal-Ligand Bifunctional Dinuclear Iridium Catalyst". . p. 5815 - 5824. Retrieved 2020/05/26.