3-hydroxybromazepam

Base Information

• Chemical Name: 3-hydroxybromazepam
• CAS No.: 13132-73-5
• Molecular Formula: C14H10 Br N3 O2
• Molecular Weight: 332.15
• Hs Code.: 2933990090
• Mol file: 13132-73-5.mol

Synonyms:2H-1,4-Benzodiazepin-2-one,7-bromo-1,3-dihydro-3-hydroxy-5-(2-pyridyl)- (8CI); 3-Hydroxybromazepam

Chemical Property of 3-hydroxybromazepam

Chemical Property:

• Vapor Pressure: 9.41E-13mmHg at 25°C
• Melting Point: 208-210°C (dec.)
• Boiling Point: 546°Cat760mmHg
• Flash Point: 284°C
• PSA: 74.58000
• Density: 1.71g/cm³
• LogP: 1.52560
• Storage Temp.: Controlled Substance, -20°C Freezer

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Major metabolite of Bromazepam (B678500)

Technology Process of 3-hydroxybromazepam

There total 8 articles about 3-hydroxybromazepam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

7-bromo-1,3-dihydro-3-acetoxy-5-(2'-pyridyl)-2H-1,4-benzodiazepin-2-one (13132-88-2) → 7-bromo-1,3-dihydro-3-hydroxy-5-(2'-pyridyl)-2H-1,4-benzodiazepin-2-one (13132-73-5)

Guidance literature:

With sodium methylate; In methanol; dichloromethane; for 1h; Ambient temperature;

Reference yield:

[5-bromo-2-(2-chloro-acetylamino)-phenyl]-pyridin-2-yl-methanone (E)-oxime (1770-93-0,13132-60-0) → 7-bromo-1,3-dihydro-3-hydroxy-5-(2'-pyridyl)-2H-1,4-benzodiazepin-2-one (13132-73-5) + 7-bromo-4-oxy-5-pyridin-2-yl-1,3-dihydro-benzo[e][1,4]diazepin-2-one (1694-67-3) + 8-bromo-6-pyridin-2-yl-1H-benzo[d][1,2,6]oxadiazocin-2-one (13132-70-2)

Guidance literature:

With sodium methylate; In 1,4-dioxane; for 20h; Ambient temperature;

DOI:10.1021/jo01283a013

Reference yield:

2-(2'-hexaminiumacetyl)amino-5'-bromobenzoylpyridine bromide (77616-96-7) → 7-bromo-1,3-dihydro-3-hydroxy-5-(2'-pyridyl)-2H-1,4-benzodiazepin-2-one (13132-73-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 84.6 percent / ethanol; H₂O / 24 h / Heating

2: 1.) potassium iodide; 2.) lead tetraacetate / 1.) glacial CH₃COOH, 60 dec C, 15-20 min; 2.) 1 h.

3: 87 percent / sodium methoxide / CH₂Cl₂; methanol / 1 h / Ambient temperature

With lead(IV) acetate; sodium methylate; potassium iodide; In methanol; ethanol; dichloromethane; water;

upstream raw materials:

[5-bromo-2-(2-chloro-acetylamino)-phenyl]-pyridin-2-yl-methanone (E)-oxime

7-bromo-1,3-dihydro-3-acetoxy-5-(2'-pyridyl)-2H-1,4-benzodiazepin-2-one

2-(2'-hexaminiumacetyl)amino-5'-bromobenzoylpyridine bromide

N,N'-methylenebis<3-(2'-o-pyridoyl-4-bromo)phenyl>-4-imidazolidinone

Refernces