9-(4-methoxy)-5-(4'-nitrophenyl)-3H,13aH-quinolino[3,2-f][1,2,4]triazolo[4,3-b][1,2,4]triazepine

Base Information

• Chemical Name: 9-(4-methoxy)-5-(4'-nitrophenyl)-3H,13aH-quinolino[3,2-f][1,2,4]triazolo[4,3-b][1,2,4]triazepine
• CAS No.: 1236182-61-8
• Molecular Formula: C₁₉H₁₃N₇O₃
• Molecular Weight: 387.357
• Mol file: 1236182-61-8.mol

Synonyms:9-(4-methoxy)-5-(4'-nitrophenyl)-3H,13aH-quinolino[3,2-f][1,2,4]triazolo[4,3-b][1,2,4]triazepine

Chemical Property of 9-(4-methoxy)-5-(4'-nitrophenyl)-3H,13aH-quinolino[3,2-f][1,2,4]triazolo[4,3-b][1,2,4]triazepine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-(4-methoxy)-5-(4'-nitrophenyl)-3H,13aH-quinolino[3,2-f][1,2,4]triazolo[4,3-b][1,2,4]triazepine

There total 5 articles about 9-(4-methoxy)-5-(4'-nitrophenyl)-3H,13aH-quinolino[3,2-f][1,2,4]triazolo[4,3-b][1,2,4]triazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

3,4-diamino-5-(p-nitrophenyl)-1,2,4-triazole (957768-24-0) + 2-chloro-6-methoxyquinolin-3-carboxaldehyde (73568-29-3) → 9-(4-methoxy)-5-(4'-nitrophenyl)-3H,13aH-quinolino[3,2-f][1,2,4]triazolo[4,3-b][1,2,4]triazepine (1236182-61-8)

Guidance literature:

With toluene-4-sulfonic acid; N,N-dimethyl-formamide; for 0.1h; Microwave irradiation;

Reference yield:

4-nitrobenzoic acid methyl ester (619-50-1) → 9-(4-methoxy)-5-(4'-nitrophenyl)-3H,13aH-quinolino[3,2-f][1,2,4]triazolo[4,3-b][1,2,4]triazepine (1236182-61-8)

Guidance literature:

Multi-step reaction with 5 steps

1: hydrazine hydrate / ethanol / Reflux

2: hydrogenchloride / water / Heating

3: sulfuric acid

4: hydrazine hydrate / ethanol / Reflux

5: 0.08 h / Microwave irradiation; Ionic liquid

With hydrogenchloride; sulfuric acid; hydrazine hydrate; In ethanol; water;

DOI:10.1016/j.bmcl.2011.06.007

Reference yield:

1-(4-nitrobenzoyl)thiosemicarbazide (836-16-8) → 9-(4-methoxy)-5-(4'-nitrophenyl)-3H,13aH-quinolino[3,2-f][1,2,4]triazolo[4,3-b][1,2,4]triazepine (1236182-61-8)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid

2: hydrazine hydrate / ethanol / Reflux

3: 0.08 h / Microwave irradiation; Ionic liquid

With sulfuric acid; hydrazine hydrate; In ethanol;

DOI:10.1016/j.bmcl.2011.06.007

upstream raw materials:

3,4-diamino-5-(p-nitrophenyl)-1,2,4-triazole

2-chloro-6-methoxyquinolin-3-carboxaldehyde

4-nitrobenzoic acid methyl ester

1-(4-nitrobenzoyl)thiosemicarbazide

Refernces

• 1、 Gupta, Monika,Paul, Satya,Gupta, Rajive. "One-pot synthesis of antifungal active 9-substituted-3-aryl-5H,13aH- quinolino [3,2-/][1,2,4]triazolo [4,3-b] [1,2,4]triazepines". experimental part. p. 475 - 481. Retrieved 2010/10/03.