Technology Process of cyclo<3-(2-naphthalenyl)-D-alanyl-2,2-dimethyl-β-alanyl-(2S)-2-hydroxy-4-(methylpentanoyl)-(2E,5S,6R,7E)-5-hydroxy-6-methyl-8-phenyl-2,7-octadienoyl>
There total 7 articles about cyclo<3-(2-naphthalenyl)-D-alanyl-2,2-dimethyl-β-alanyl-(2S)-2-hydroxy-4-(methylpentanoyl)-(2E,5S,6R,7E)-5-hydroxy-6-methyl-8-phenyl-2,7-octadienoyl> which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
pentafluorophenyl diphenyl-phosphinate; N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 25 ℃;
Yield given;
DOI:10.1021/jm980706s
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 80 percent / 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide / dimethylformamide / 28 h / Ambient temperature
2: 78 percent / 48 percent aq. HF / acetonitrile / 5 h / 0 - 25 °C
3: 79 percent / 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide, 4-(dimethylamino)pyridine / CH2Cl2 / 0.3 h / Ambient temperature
4: 78 percent / N,O-bis(trimethylsilyl)acetamide / dimethylformamide / 55 - 60 °C
5: trifluoroacetic acid / 3 h / 25 °C
6: N,N-diisopropylethylamine, pentafluorophenyl diphenylphosphinate / dimethylformamide / 25 °C
With
dmap; N,O-bis-(trimethylsilyl)-acetamide; pentafluorophenyl diphenyl-phosphinate; hydrogen fluoride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
In
dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm980706s
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 100 percent / 1 N aq. LiOH / acetone / 23.5 h / Ambient temperature
2: 80 percent / 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide / dimethylformamide / 28 h / Ambient temperature
3: 78 percent / 48 percent aq. HF / acetonitrile / 5 h / 0 - 25 °C
4: 79 percent / 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide, 4-(dimethylamino)pyridine / CH2Cl2 / 0.3 h / Ambient temperature
5: 78 percent / N,O-bis(trimethylsilyl)acetamide / dimethylformamide / 55 - 60 °C
6: trifluoroacetic acid / 3 h / 25 °C
7: N,N-diisopropylethylamine, pentafluorophenyl diphenylphosphinate / dimethylformamide / 25 °C
With
dmap; lithium hydroxide; N,O-bis-(trimethylsilyl)-acetamide; pentafluorophenyl diphenyl-phosphinate; hydrogen fluoride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
In
dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1021/jm980706s