4-(2,3-Epoxypropyl)morpholine

Base Information

• Chemical Name: 4-(2,3-Epoxypropyl)morpholine
• CAS No.: 6270-19-5
• Molecular Formula: C7H13 N O2
• Molecular Weight: 143.186
• Hs Code.: 2934999090
• European Community (EC) Number: 228-450-5
• NSC Number: 34004
• DSSTox Substance ID: DTXSID90902766
• Nikkaji Number: J211.504B
• Mol file: 6270-19-5.mol

Synonyms:4-(2,3-Epoxypropyl)morpholine;6270-19-5;4-(oxiran-2-ylmethyl)morpholine;4-[(oxiran-2-yl)methyl]morpholine;Morpholine, 4-(oxiranylmethyl)-;EINECS 228-450-5;4-(2-Oxiranylmethyl)morpholine;NSC34004;4-Glycidylmorpholine;NoName_3320;4-oxiranylmethyl-morpholine;SCHEMBL336214;1-morpholino-2,3-epoxypropane;3-morpholino-1,2-epoxypropane;DTXSID90902766;4-(2-Oxiranylmethyl)morpholine #;BCP21274;BCP32562;1,2-epoxy-3-morpholin-4-ylpropane;MFCD00047415;NSC 34004;NSC-34004;AKOS000200850;AKOS016050036;AB89263;SB46787;AS-61567;4-(2-Oxiranylmethyl)morpholine, AldrichCPR;CS-0008407;FT-0636055;FT-0686178;EN300-13559;D72466;Z90667558;F9995-2527;4-(Oxiran-2-ylmethyl)morpholine

Chemical Property of 4-(2,3-Epoxypropyl)morpholine

Chemical Property:

• Vapor Pressure: 0.2mmHg at 25°C
• Boiling Point: 93-98°C 12mm
• PKA: 6.90±0.10(Predicted)
• Flash Point: 88.4°C
• PSA: 25.00000
• Density: 1.05
• LogP: -0.34470
• XLogP3: -0.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 143.094628657
• Heavy Atom Count: 10
• Complexity: 112

Purity/Quality:

98%min ^*data from raw suppliers

4-(2,3-Epoxypropyl)morpholine 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 36/37/38-41-37/38-22
• Safety Statements: 26-36/37/39-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1CC2CO2

Technology Process of 4-(2,3-Epoxypropyl)morpholine

There total 4 articles about 4-(2,3-Epoxypropyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.8%

morpholine (110-91-8,99108-56-2) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → 4-(oxiran-2-ylmethyl)morpholine (6270-19-5)

Guidance literature:

morpholine; epichlorohydrin; In tert-butyl alcohol; at 0 - 20 ℃; Cooling with ice-water;

With potassium tert-butylate; In tetrahydrofuran; tert-butyl alcohol; at 10 ℃; Cooling with ice-water;

Reference yield: 87.0%

1-chloro-3-(4-morpholinyl)-2-propanol (40893-69-4) → 4-(oxiran-2-ylmethyl)morpholine (6270-19-5)

Guidance literature:

With potassium hydroxide; In xylene; at 20 ℃; for 12h;

DOI:10.1134/S1070428006120141

Reference yield:

γ-morpholine-β-hydroxy propyl chloride → 4-(oxiran-2-ylmethyl)morpholine (6270-19-5)

Guidance literature:

With sodium ethanolate; In tetrahydrofuran; at 20 ℃; for 5h;

upstream raw materials:

morpholine

epichlorohydrin

1-chloro-3-(4-morpholinyl)-2-propanol

Downstream raw materials:

3-morpholin-4-yl-propane-1,2-diol

3-amino-5-(morpholinomethyl)oxazolidin-2-one

4,4'-bis(2-hydroxy-3-morpholinopropylthiomethyl)biphenyl

4,4'-bis(2-hydroxy-3-morpholinopropylthio)diphenyl ether

Refernces

• 1、 Sreekumari, Rahul B.,Saraswati, Bindu,Chellan, Shiju,Gupta, Gopal,Lal, Nand. "Homopiperazine derived female controlled vaginal trichomonacidal contraceptive: An addition to structure-activity relationship". . p. 773 - 783. Retrieved 2018/11/30.
• 2、 Mishra, Kunj B.,Shashi, Somesh,Tiwari, Vinod K.. "Metal free synthesis of morpholine fused [5,1-c] triazolyl glycoconjugates via glycosyl azido alcohols". . p. 86840 - 86848. Retrieved 2015/11/03.