N-norcadeine methyl ether

Base Information

• Chemical Name: N-norcadeine methyl ether
• CAS No.: 173677-19-5
• Molecular Formula: C₁₈H₂₁NO₃
• Molecular Weight: 299.37
• Mol file: 173677-19-5.mol

Synonyms:N-norcadeine methyl ether

Chemical Property of N-norcadeine methyl ether

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of N-norcadeine methyl ether

There total 6 articles about N-norcadeine methyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

codeine methyl ether N-oxide hydrochloride → N-norcadeine methyl ether (173677-19-5) + codeine-6-methyl ether (2859-16-7)

Guidance literature:

codeine methyl ether N-oxide hydrochloride; With ferrocene; In chloroform; at 50 ℃; for 22h;

With sodium hydroxide; In chloroform; water;

DOI:10.1016/j.bmcl.2010.06.031

Reference yield: 79.0%

C19H23NO4*C8H6O4 → N-norcadeine methyl ether (173677-19-5) + codeine-6-methyl ether (2859-16-7)

Guidance literature:

With iron(II) sulfate; In methanol; at 20 ℃; for 6h;

DOI:10.1016/j.bmcl.2006.03.017

Reference yield: 70.0%

C19H23NO4*HNO3 → N-norcadeine methyl ether (173677-19-5) + codeine-6-methyl ether (2859-16-7)

Guidance literature:

With iron(II) sulfate; In methanol; at 20 ℃; for 6h;

DOI:10.1016/j.bmcl.2006.03.017

Refernces

• 1、 Kok, Gaik B.,Scammells, Peter J.. "N-Demethylation of N-methyl alkaloids with ferrocene". supporting information; experimental part. p. 4499 - 4502. Retrieved 2010/09/15.
• 2、 Thavaneswaran, Shanti,Scammells, Peter J.. "Further investigation of the N-demethylation of tertiary amine alkaloids using the non-classical Polonovski reaction". . p. 2868 - 2871. Retrieved 2007/10/03.