1-ethyl-4-isopropylcyclohexanecarboxylic acid methyl ester

Base Information

• Chemical Name: 1-ethyl-4-isopropylcyclohexanecarboxylic acid methyl ester
• CAS No.: 1210878-84-4
• Molecular Formula: C₁₃H₂₄O₂
• Molecular Weight: 212.332
• Mol file: 1210878-84-4.mol

Synonyms:1-ethyl-4-isopropylcyclohexanecarboxylic acid methyl ester

Chemical Property of 1-ethyl-4-isopropylcyclohexanecarboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 1-ethyl-4-isopropylcyclohexanecarboxylic acid methyl ester

There total 2 articles about 1-ethyl-4-isopropylcyclohexanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

p-menthan-7-oic acid methyl ester (175284-00-1) + ethyl iodide (75-03-6) → 1-ethyl-4-isopropylcyclohexanecarboxylic acid methyl ester (1210878-84-4)

Guidance literature:

p-menthan-7-oic acid methyl ester; With lithium diisopropyl amide; In tetrahydrofuran; at -78 - 20 ℃; for 0.75h; Inert atmosphere;

ethyl iodide; In tetrahydrofuran; at -78 - 20 ℃;

Reference yield:

4-isopropyl cyclohexane carboxylic acid (62067-45-2) → 1-ethyl-4-isopropylcyclohexanecarboxylic acid methyl ester (1210878-84-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride / 1,3-dioxane / 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.75 h / -78 - 20 °C / Inert atmosphere

2.2: -78 - 20 °C

With hydrogenchloride; lithium diisopropyl amide; In tetrahydrofuran; 1,3-dioxane;

Reference yield: 86.0%

1-ethyl-4-isopropylcyclohexanecarboxylic acid methyl ester (1210878-84-4) → 1-ethyl-4-isopropylcyclohexanecarboxylic acid (1210878-87-7)

Guidance literature:

1-ethyl-4-isopropylcyclohexanecarboxylic acid methyl ester; With water; potassium hydroxide; In tetrahydrofuran; ethanol; at 150 ℃; for 2h; Pressure vessel; Microwave irradiation;

With hydrogenchloride; In water;

upstream raw materials:

p-menthan-7-oic acid methyl ester

ethyl iodide

4-isopropyl cyclohexane carboxylic acid

Downstream raw materials:

1-ethyl-4-isopropylcyclohexanecarboxylic acid

Refernces