Pyridoxine

Base Information

• Chemical Name: Pyridoxine
• CAS No.: 65-23-6
• Deprecated CAS: 2087491-32-3
• Molecular Formula: C8H11NO3
• Molecular Weight: 169.18
• Hs Code.: 29362500
• European Community (EC) Number: 200-603-0
• NSC Number: 759148
• UNII: KV2JZ1BI6Z
• DSSTox Substance ID: DTXSID4023541
• Nikkaji Number: J2.095.349G,J2.356F
• Wikipedia: Pyridoxine
• Wikidata: Q423746
• NCI Thesaurus Code: C62619
• RXCUI: 684879
• Metabolomics Workbench ID: 37154
• ChEMBL ID: CHEMBL1364
• Mol file: 65-23-6.mol

Synonyms:Pyridoxin;Pyridoxine;Pyridoxine Hydrochloride;Pyridoxol;Pyridoxol Hydrochloride;Rodex

Chemical Property of Pyridoxine

Chemical Property:

• Appearance/Colour: crystalline solid
• Melting Point: 214-215 °C(lit.)
• Refractive Index: 1.5100 (estimate)
• Boiling Point: 491.9 °C at 760 mmHg
• PKA: pKa 5.00(H2O t = 25.0 I = 0.15 (mixed)) (Uncertain)
• Flash Point: 251.3 °C
• PSA: 73.58000
• Density: 1.353 g/cm³
• LogP: 0.08020
• Storage Temp.: 2-8°C
• Solubility.: H2O: 0.1?g/mL at?20?°C, clear, colorless
• XLogP3: -0.8
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 169.07389321
• Heavy Atom Count: 12
• Complexity: 142

Purity/Quality:

98% ^*data from raw suppliers

Pyridoxine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi:Irritant
• Statements: R36/37/38:
• Safety Statements: S26:; S36:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Biological Agents -> Vitamins and Derivatives
• Canonical SMILES: CC1=NC=C(C(=C1O)CO)CO
• Recent ClinicalTrials: Protecting Households On Exposure to Newly Diagnosed Index Multidrug-Resistant Tuberculosis Patients
• Recent EU Clinical Trials: The effect of Ezetimibe or pyridoxine in Patients with Primary Biliary Cirrhosis.
• Recent NIPH Clinical Trials: Prospective non- control non- randomized, open-label study about efficacy of vitamin B6 for inherited GPI deficiency
• Description: Pyridoxine hydrochloride provides pyridoxine, which is also known as vitamin B6. Vitamin B6 is naturally found in foods such as cereals, beans, vegetables, liver, meat, and eggs.? Vitamin B6 functionalizes as a coenzyme in the metabolism of protein, carbohydrate, and fat. Vitamin 6 is needed to maintain the health of nerves, skin, and red blood cells. Pyridoxine is used to prevent or treat vitamin B6 deficiency caused by inadequate dietary intake. It is also used to treat drug induced deficiency in patients taking isoniazid or oral contraceptives.
• Physical properties: It is one kind of B vitamins, containing pyridoxine or pyridoxal or pyridoxamine. Appearance: colorless crystals at room temperature. Solubility: soluble in water and ethanol. Stability: stable in acid liquor but easily destroyed in alkali liquor. Pyridoxol is resistant to high temperature, but pyridoxal and pyridoxamine are not.
• Uses: antibacterial pyridoxine HCL is a skin-conditioning agent that is also widely used in hair products. Vitamin B6, a water-soluble vitamin with a solubility of 1 g in 5 ml of water. It functions in the utilization of protein and is an essential nutrient in enzyme reactions. It is necessary for proper growth. During processing, there is a loss due to leaching of the vitamin in water. It is destroyed by high temperatures, high irradiation, and exposure to light. During storage, loss increases with temperature and storage time. It is found in liver, eggs, and meats.
• Indications: Vitamin B6 deficiency
• Clinical Use: Pyridoxine is indicated in the treatment and prevention of known or suspected vitamin B6 deficiency, which is most likely to occur in the setting of alcoholism in developed countries. At least seven genetic disorders that result in a vitamin B6 deficiency syndrome in the presence of an adequate dietary intake have been identified. These result from defects in enzymes that are responsible for the bioactivation or utilization of vitamin B6.

Technology Process of Pyridoxine

There total 59 articles about Pyridoxine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.8%

8-methyl-3-(propan-2-yl)-1H,3H,5H-[1,3]dioxepino[5,6-c]pyridin-9-yl acetate (92671-67-5) → 5-hydroxy-6-methyl-3,4-pyridinedimethanol (65-23-6)

Guidance literature:

With hydrogenchloride; In ethanol; for 6h; Reflux;

Reference yield: 95.9%

8-methyl-3-propyl-1H,3H,5H-[1,3]dioxepino[5,6-c]pyridin-9-yl acetate → 5-hydroxy-6-methyl-3,4-pyridinedimethanol (65-23-6)

Guidance literature:

With hydrogenchloride; In ethanol; for 5h; Reflux;

Reference yield: 95.0%

butyl 2-methyl-3-hydroxypyridine-4,5-dicarboxylate → 5-hydroxy-6-methyl-3,4-pyridinedimethanol (65-23-6)

Guidance literature:

With sodium tetrahydroborate; benzoic acid; In tetrahydrofuran; at 40 - 60 ℃; for 2h; Reagent/catalyst; Solvent; Temperature;

upstream raw materials:

4,5-bis-hydroxymethyl-2-methyl-pyridin-3-ylamine

5-hydroxy-6-methyl-pyridine-3,4-dicarboxylic acid

5-hydroxy-6-methyl-pyridine-3,4-dicarboxylic acid dimethyl ester

5-acetoxy-6-methyl-pyridine-3,4-dicarboxylic acid dimethyl ester

Downstream raw materials:

3-hydroxy-4,5-bis-hydroxymethyl-2-methyl-1-phenacyl-pyridinium; bromide

4-deoxypyridoxine

5-hydroxy-4-hydroxymethyl-6-methyl-pyridine-3-carbaldehyde

7-hydroxy-6-methyl-1,3-dihydrofuro<3,4-c>pyridin

Refernces

• 1、 Tazoe, Masaaki,Ichikawa, Keiko,Hoshino, Tatsuo. "Purification and characterization of pyridoxine 5′-phosphate phosphatase from Sinorhizobium meliloti". . p. 2277 - 2284. Retrieved 2005.
• 2、 -. "Preparation method of high content vitamin B6". Paragraph 0043-0044; 0051-0052. . Retrieved 2019/07/16.
• 3、 -. "Method for preparing vitamin B6 by reduction method". Paragraph 0020; 0023; 0032; 0033. . Retrieved 2018/09/08.