Technology Process of tert-butyldiphenylsilanecarboxylic acid
There total 5 articles about tert-butyldiphenylsilanecarboxylic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
tert-butylchlorodiphenylsilane;
With
lithium;
In
tetrahydrofuran;
at 20 ℃;
for 5h;
Inert atmosphere;
carbon dioxide;
In
tetrahydrofuran;
at 20 ℃;
for 0.333333h;
Inert atmosphere;
DOI:10.1021/ja208652n
- Guidance literature:
-
1-trimethylsiloxy-1-t-butyldiphenylsilylethylene;
With
ozone;
In
ethyl acetate;
at -78 ℃;
for 0.416667h;
With
triphenylphosphine;
In
ethyl acetate;
at -78 - 20 ℃;
Inert atmosphere;
DOI:10.1021/acs.joc.9b03350
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: tert.-butyl lithium / tetrahydrofuran; pentane / 1 h / -78 °C / Inert atmosphere
1.2: 24 h / 0 - 20 °C / Inert atmosphere
2.1: hydrogenchloride / acetone; water / 20 h / 20 °C / Inert atmosphere
3.1: lithium diisopropyl amide; n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere
3.2: 15 h / -78 - 20 °C / Inert atmosphere
4.1: ozone / ethyl acetate / 0.42 h / -78 °C
4.2: -78 - 20 °C / Inert atmosphere
With
hydrogenchloride; n-butyllithium; tert.-butyl lithium; ozone; lithium diisopropyl amide;
In
tetrahydrofuran; hexane; water; ethyl acetate; acetone; pentane;
DOI:10.1021/acs.joc.9b03350
