C₁₄H₁₆BrN₃O

Base Information

• Chemical Name: C₁₄H₁₆BrN₃O
• CAS No.: 1433946-58-7
• Molecular Formula: C₁₄H₁₆BrN₃O
• Molecular Weight: 322.205
• Mol file: 1433946-58-7.mol

Synonyms:C₁₄H₁₆BrN₃O

Chemical Property of C₁₄H₁₆BrN₃O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₄H₁₆BrN₃O

There total 5 articles about C₁₄H₁₆BrN₃O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S,4S)-2-[5-(4-bromo-phenyl)-1H-imidazol-2-yl]-4-methoxy-pyrrolidine-1-carboxylic acid tert-butyl ester (1373164-86-3) → C14H16BrN3O (1433946-58-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 5h;

Reference yield:

(2S,4S)-1-tert-butyl 2-methyl 4-methoxypyrrolidine-1,2-dicarboxylate (215918-38-0) → C14H16BrN3O (1433946-58-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: lithium hydroxide / tetrahydrofuran / 5 h / 20 °C

1.2: pH 5

2.1: acetonitrile / 5 h / 20 °C / Inert atmosphere

3.1: ammonium acetate / toluene / 6 h / 100 °C / Sealed tube

4.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

With ammonium acetate; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; dichloromethane; toluene; acetonitrile;

Reference yield:

(2S,4S)-N-tert-butoxycarbonyl-4-hydroxyproline methyl ester (74844-91-0,114676-69-6,135042-17-0,227935-38-8,102195-79-9) → C14H16BrN3O (1433946-58-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

1.2: 4 h / 0 - 20 °C / Inert atmosphere

2.1: lithium hydroxide / tetrahydrofuran / 5 h / 20 °C

2.2: pH 5

3.1: acetonitrile / 5 h / 20 °C / Inert atmosphere

4.1: ammonium acetate / toluene / 6 h / 100 °C / Sealed tube

5.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

With ammonium acetate; sodium hydride; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;

upstream raw materials:

(2S,4S)-N-tert-butoxycarbonyl-4-hydroxyproline methyl ester

(2S,4S)-1-tert-butyl 2-methyl 4-methoxypyrrolidine-1,2-dicarboxylate

(2S,4S)-1-[(tert-butoxy)carbonyl]-4-methoxypyrrolidine-2-carboxylic acid

(2S,4S)-2-[5-(4-bromo-phenyl)-1H-imidazol-2-yl]-4-methoxy-pyrrolidine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

methyl ((2S)-1-((3aS,6aS)-2-(5-(4-(2-((1S,2S)-2-carbamoylcyclopentyl)-1H-imidazol-5-yl)-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)hexahydrocyclopenta[b]pyrrol-1(2H)-yl)-3-methyl-1-oxobutan-2-yl)carbamate

methyl ((S)-1-((2S,4S)-4-methoxy-2-(5-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate

methyl ((S)-3-methyl-1-oxo-1-((2S,3aS,6aS)-2-(5-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-imidazol-2-yl)hexahydrocyclopenta[b]pyrrol-1(2H)-yl)butan-2-yl)carbamate

(1R,2R)-2-(5-(4’-(2-((2S,3aS,6aS)-1-((S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)octahydrocyclopenta[b]pyrrol-2-yl)-1H-imidazol-5-yl)-[1,1‘-biphenyl]-4-yl)-1H-imidazol-2-yl)cyclopentanecarboxylic acid

Refernces