2-(hydroxymethyl)thiophenoxyacetone

Base Information

• Chemical Name: 2-(hydroxymethyl)thiophenoxyacetone
• CAS No.: 130966-65-3
• Molecular Formula: C₁₀H₁₂O₂S
• Molecular Weight: 196.27
• Mol file: 130966-65-3.mol

Synonyms:2-(hydroxymethyl)thiophenoxyacetone

Chemical Property of 2-(hydroxymethyl)thiophenoxyacetone

Chemical Property:

Purity/Quality:

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Technology Process of 2-(hydroxymethyl)thiophenoxyacetone

There total 2 articles about 2-(hydroxymethyl)thiophenoxyacetone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Thiosalicylic acid (147-93-3) → 2-(hydroxymethyl)thiophenoxyacetone (130966-65-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) LiAlH₄, 2.) EtOAc, H₂O / 1a.) THF, 0-5 deg C, 1b.) RT, 1h, 2.) 0-5 deg C, 30 min

2: tetrahydrofuran / 0.33 h / 0 - 5 °C

With lithium aluminium tetrahydride; water; ethyl acetate; In tetrahydrofuran;

Reference yield:

2-(hydroxymethyl)thiophenoxide + chloroacetone (78-95-5) → 2-(hydroxymethyl)thiophenoxyacetone (130966-65-3)

Guidance literature:

In tetrahydrofuran; at 0 - 5 ℃; for 0.333333h; Yield given;

Reference yield: 79.0%

2-(hydroxymethyl)thiophenoxyacetone (130966-65-3) → 2-acetyl benzo[b]thiophene (22720-75-8)

Guidance literature:

With pyridine-SO₃ complex; triethylamine; In dichloromethane; dimethyl sulfoxide;

upstream raw materials:

chloroacetone

Thiosalicylic acid

Downstream raw materials:

2-acetyl benzo[b]thiophene

Refernces