Technology Process of N-((7,7-dimethylcyclohept-1-enyl)methyl)-3-fluoro-N-methylaniline hydrochloride
There total 8 articles about N-((7,7-dimethylcyclohept-1-enyl)methyl)-3-fluoro-N-methylaniline hydrochloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
diethyl ether;
at 20 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: sodium hydroxide / water; ethanol / 9 h / Reflux
2: zinc(II) iodide / dichloromethane / 2 h / 20 °C
3: hydrogenchloride / tetrahydrofuran; water / 20 °C
4: thionyl chloride; pyridine / 2 h / 20 °C
5: diisobutylaluminium hydride / dichloromethane; hexane / 2 h / -78 °C / Inert atmosphere
6: acetic acid; sodium cyanoborohydride / methanol / 2 h / 20 °C
7: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C
8: hydrogenchloride / diethyl ether / 2 h / 20 °C
With
pyridine; hydrogenchloride; thionyl chloride; sodium hydride; diisobutylaluminium hydride; sodium cyanoborohydride; acetic acid; sodium hydroxide; zinc(II) iodide;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: hydrogenchloride / tetrahydrofuran; water / 20 °C
2: thionyl chloride; pyridine / 2 h / 20 °C
3: diisobutylaluminium hydride / dichloromethane; hexane / 2 h / -78 °C / Inert atmosphere
4: acetic acid; sodium cyanoborohydride / methanol / 2 h / 20 °C
5: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C
6: hydrogenchloride / diethyl ether / 2 h / 20 °C
With
pyridine; hydrogenchloride; thionyl chloride; sodium hydride; diisobutylaluminium hydride; sodium cyanoborohydride; acetic acid;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; water; N,N-dimethyl-formamide;