1-(3ξ-cyclohexyl-3ξ-phenyl-allyl)-piperidine

Base Information

• Chemical Name: 1-(3ξ-cyclohexyl-3ξ-phenyl-allyl)-piperidine
• CAS No.: 67562-42-9
• Molecular Formula: C₂₀H₂₉N
• Molecular Weight: 283.457
• Mol file: 67562-42-9.mol

Synonyms:1-(3ξ-cyclohexyl-3ξ-phenyl-allyl)-piperidine

Chemical Property of 1-(3ξ-cyclohexyl-3ξ-phenyl-allyl)-piperidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Deshydroxy Trihexyphenidyl is an impurity of D,L-Trihexyphenidyl Hydrochloride (T795000). Artane is an anticholinergic tertiary amine that can gain access to the CNS. It is used to treat parkinsonism and the extrapyramidal side effects of anti-psychotic drugs. The drug is a muscarinic antagonist that qualitatively resembles the belladonna alkaloids in its pharmacological actions and side effects.

Technology Process of 1-(3ξ-cyclohexyl-3ξ-phenyl-allyl)-piperidine

There total 4 articles about 1-(3ξ-cyclohexyl-3ξ-phenyl-allyl)-piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclohexylmagnesium bromide (931-50-0) → 1-(3ξ-cyclohexyl-3ξ-phenyl-allyl)-piperidine (67562-42-9)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether

2: hydrochloric acid , concentrated aqueous; acetic acid

With hydrogenchloride; diethyl ether; acetic acid;

Reference yield:

trihexyphenidyl (144-11-6) → 1-(3ξ-cyclohexyl-3ξ-phenyl-allyl)-piperidine (67562-42-9)

Guidance literature:

With hydrogenchloride; acetic acid;

Reference yield:

1-phenyl-3-(piperidin-1-yl)propan-1-one (73-63-2) → 1-(3ξ-cyclohexyl-3ξ-phenyl-allyl)-piperidine (67562-42-9)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether

2: hydrochloric acid , concentrated aqueous; acetic acid

With hydrogenchloride; diethyl ether; acetic acid;

upstream raw materials:

trihexyphenidyl

1-phenyl-3-(piperidin-1-yl)propan-1-one

Pridinol

cyclohexylmagnesium bromide

Downstream raw materials:

1-(3-cyclohexyl-3-phenyl-propyl)-piperidine