N-Methylhexadecylamine

Base Information

• Chemical Name: N-Methylhexadecylamine
• CAS No.: 13417-08-8
• Molecular Formula: C17H37 N
• Molecular Weight: 255.487
• Hs Code.: 2921199090
• European Community (EC) Number: 236-514-9
• DSSTox Substance ID: DTXSID40158579
• Nikkaji Number: J317.871D
• Wikidata: Q83026876
• Mol file: 13417-08-8.mol

Synonyms:N-Methylhexadecylamine;n-methylhexadecan-1-amine;13417-08-8;1-Hexadecanamine,N-methyl-;HEXADECYL(METHYL)AMINE;1-Hexadecanamine, N-methyl-;EINECS 236-514-9;Methylhexadecylamine;starbld0007013;SCHEMBL967648;DTXSID40158579;AKOS005302515;FT-0671813;EN300-18534480

Chemical Property of N-Methylhexadecylamine

Chemical Property:

• Vapor Pressure: 0.000713mmHg at 25°C
• Melting Point: 36°C
• Refractive Index: 1.4476 (estimate)
• Boiling Point: 307.7°Cat760mmHg
• PKA: 10.78±0.10(Predicted)
• Flash Point: 127.9°C
• PSA: 12.03000
• Density: 0.803g/cm³
• LogP: 6.07800
• XLogP3: 7.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 15
• Exact Mass: 255.292600184
• Heavy Atom Count: 18
• Complexity: 134

Purity/Quality:

98%Min ^*data from raw suppliers

N-Methylhexadecylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCCCCCCCCCCCCCNC
• Uses: N-Methylhexadecylamine (cas# 13417-08-8) is a compound useful in organic synthesis.

Technology Process of N-Methylhexadecylamine

There total 18 articles about N-Methylhexadecylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

S-ethyl-S-3<(hexadecyloxy)sulfonyl>propyl-S-methylsulfonium methylsulfate (85577-40-8) + methylamine (74-89-5) → N-methyl-1-hexadecanamine (13417-08-8)

Guidance literature:

In 1,2-dimethoxyethane; water; at 2 ℃; for 24h;

Reference yield: 89.0%

N-Hexadecyl-N-methyl-2-(tetrahydro-pyran-2-yloxymethyl)-benzamide (211438-72-1) → N-methyl-1-hexadecanamine (13417-08-8)

Guidance literature:

With water; acetic acid; In tetrahydrofuran; at 60 ℃; for 4h;

DOI:10.1016/S0040-4039(98)00990-3

Reference yield: 88.0%

N-methylhexadecanamide (7388-58-1) → N-methyl-1-hexadecanamine (13417-08-8)

Guidance literature:

N-methylhexadecanamide; With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 - 25 ℃; for 3h; Industry scale; Reflux;

With water; sodium hydroxide; In tetrahydrofuran;

upstream raw materials:

benzyl-hexadecyl-methyl-amine

1-Chlorohexadecan

methylamine

methyl bromide

Downstream raw materials:

hexadecyl-bis-(2-hydroxy-ethyl)-methyl-ammonium; chloride

N-methyl-N-(β-hydroxyethyl)-n-hexadecylamine

Refernces

• 1、 Giansanti, Luisa,Mauceri, Alessandro,Galantini, Luciano,Altieri, Barbara,Piozzi, Antonella,Mancini, Giovanna. "Glucosylated pH-sensitive liposomes as potential drug delivery systems". . p. 113 - 119. Retrieved 2016.
• 2、 Biswas, Nandita,Srimani, Dipankar. "Ru-Catalyzed Selective Catalytic Methylation and Methylenation Reaction Employing Methanol as the C1 Source". . p. 10544 - 10554. Retrieved 2021/07/31.
• 3、 Wong, Yue-Ling,Hubieki,Curfman, Christopher L,Doncel, Gustavo F,Dudding, Travis C,Savle, Prashant S,Gandour, Richard D. "A structure-activity study of spermicidal and anti-HIV properties of hydroxylated cationic surfactants". . p. 3599 - 3608. Retrieved 2007/10/03.