GENISTEIN TRIMETHYL ETHER

Base Information

• Chemical Name: GENISTEIN TRIMETHYL ETHER
• CAS No.: 1162-82-9
• Molecular Formula: C18H16 O5
• Molecular Weight: 312.322
• Hs Code.: 2914509090
• Mol file: 1162-82-9.mol

Synonyms:Isoflavone,4',5,7-trimethoxy- (6CI,7CI,8CI); 4',5,7-Trimethoxyisoflavone;5,7,4'-Trimethoxyisoflavone; 5,7-O-Dimethylbiochanin A; Genistein trimethylether

Chemical Property of GENISTEIN TRIMETHYL ETHER

Chemical Property:

• Vapor Pressure: 2.21E-10mmHg at 25°C
• Boiling Point: 506.5°Cat760mmHg
• Flash Point: 225.5°C
• PSA: 57.90000
• Density: 1.242g/cm³
• LogP: 3.48580

Purity/Quality:

98%,99%, ^*data from raw suppliers

5,7,4'-Trimethoxyisoflavone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of GENISTEIN TRIMETHYL ETHER

There total 25 articles about GENISTEIN TRIMETHYL ETHER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

5,7-Dihydroxy-3-(4-methoxy-phenyl)-chromen-4-on (491-80-5) + dimethyl sulfate (77-78-1) → 4',5,7-trimethoxyisoflavone (1162-82-9)

Guidance literature:

With potassium carbonate; In acetone; for 18h; Heating;

Reference yield: 95.0%

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on (446-72-0) + methyl iodide (74-88-4) → 4',5,7-trimethoxyisoflavone (1162-82-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 40 ℃; for 4h;

DOI:10.1007/s10600-016-1807-0

Reference yield: 95.0%

4',5,7-trimethoxyflavanone (66074-95-1,38302-15-7) → 4',5,7-trimethoxyisoflavone (1162-82-9)

Guidance literature:

With thallium(III) toluene-p-sulfonate; In acetonitrile; for 2h; Heating;

upstream raw materials:

diazomethane

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

dimethyl sulfate

5,7-Dihydroxy-3-(4-methoxy-phenyl)-chromen-4-on

Downstream raw materials:

1-[4-(2-hydroxy-4,6-dimethoxyphenyl)-5-(4-methoxyphenyl)pyrimidin-2-yl]thiourea

Refernces

• 1、 Wang, Cai-Ling,Li, Hong-Qi,Meng, Wei-Dong,Qing, Feng-Ling. "Trifluoromethylation of flavonoids and anti-tumor activity of the trifluoromethylated flavonoid derivatives". . p. 4456 - 4458. Retrieved 2005.
• 2、 -. "3,5-diaryl pyrazole or 3,4-diaryl pyrazole derivative and application thereof". Paragraph 0030; 0031; 0032. . Retrieved 2018/06/26.
• 3、 Zheng, Xing,Yao, Xu,Liu, Yunmei,Zheng, Zitong,Cao, Jianguo,Liao, Duanfang. "Synthesis and cytotoxic activity of genistein derivatives". experimental part. p. 1296 - 1306. Retrieved 2011/10/12.