2-Methylpyrimidin-4-amine

Base Information

• Chemical Name: 2-Methylpyrimidin-4-amine
• CAS No.: 74-69-1
• Molecular Formula: C5H7N3
• Molecular Weight: 109.131
• Hs Code.: 2933599090
• NSC Number: 165370
• DSSTox Substance ID: DTXSID10304309
• Nikkaji Number: J46.537B
• Wikidata: Q63393360
• ChEMBL ID: CHEMBL4579021
• Mol file: 74-69-1.mol

Synonyms:2-methylpyrimidin-4-amine;74-69-1;2-methyl-4-pyrimidinamine;4-AMINO-2-METHYLPYRIMIDINE;2-METHYL-PYRIMIDIN-4-YLAMINE;4-PYRIMIDINAMINE, 2-METHYL-;MFCD00626295;2-methylpyrimidin-4-ylamine;4-Pyrimidinamine, 2-methyl- (9CI);8GF;NSC165370;2-methyl-4-amino-pyrimidine;SCHEMBL117690;2-Methyl-pyrimidin-4-yl amine;CHEMBL4579021;DTXSID10304309;GKVDLTTVBNOGNJ-UHFFFAOYSA-N;(2-methyl-pyrimidin-4-yl)-amine;2-METHYL-4-AMINOPYRIMIDINE;2-METHYL-4-PYRIMIDINAMINE HCL;AKOS011055700;AKOS030757258;2-methyl-4-pyrimidinamine, AldrichCPR;AB06587;CS-W018583;GS-5845;NSC-165370;AM804304;SY024243;FT-0740039;A865822;AG-690/33373005;J-510095;Q63393360;Z2092177023

Chemical Property of 2-Methylpyrimidin-4-amine

Chemical Property:

• Vapor Pressure: 0.103mmHg at 25°C
• Melting Point: 204-205℃
• Refractive Index: 1.582
• Boiling Point: 222.186 °C at 760 mmHg
• PKA: 5.99±0.10(Predicted)
• Flash Point: 110.702 °C
• PSA: 51.80000
• Density: 1.156 g/cm³
• LogP: 0.94840
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 109.063997236
• Heavy Atom Count: 8
• Complexity: 74.1

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-methyl-1,4-dihydropyrimidin-4-imine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC=CC(=N1)N

Technology Process of 2-Methylpyrimidin-4-amine

There total 3 articles about 2-Methylpyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-2-methylpyrimidine (4994-86-9) → 2-methyl-pyrimidin-4-ylamine (74-69-1)

Guidance literature:

With ethanol; ammonia; at 100 ℃; im Rohr;

Reference yield:

4-chloro-2-methylpyrimidine (4994-86-9) + ammonia (7664-41-7) → 2-methyl-pyrimidin-4-ylamine (74-69-1)

Guidance literature:

at 100 ℃; im Rohr;

Reference yield:

2-methylpyrimidine (5053-43-0) → 2-methyl-pyrimidin-4-ylamine (74-69-1)

Guidance literature:

With potassium permanganate; sodium amide; Yield given. Multistep reaction; 1) NH₃ liq., -33 deg C, few hours, 2) NH₃ liq., 0.5 h;

upstream raw materials:

4-chloro-2-methylpyrimidine

2-methylpyrimidine

ammonia

Downstream raw materials:

4-nitro-benzenesulfonic acid-(2-methyl-pyrimidin-4-ylamide)

2-(2,6-dichlorophenyl)-N-(2-methylpyrimidin-4-yl)-3H-imidazo-[4,5-c]pyridin-4-amine

N-(2-methylpyrimidin-4-yl)-5-trifluoromethylphthalamic acid tert-butyl ester

2-((2-methylpyrimidin-4-yl)carbamoyl)-4,5-bis(trifluoromethyl)benzoic acid

Refernces