3-(2-AMINO-1,3-THIAZOL-4-YL)-2H-CHROMEN-2-ONE HYDROBROMIDE

Base Information

• Chemical Name: 3-(2-AMINO-1,3-THIAZOL-4-YL)-2H-CHROMEN-2-ONE HYDROBROMIDE
• CAS No.: 61636-28-0
• Molecular Formula: C12H8 N2 O2 S
• Molecular Weight: 244.274
• Hs Code.: 2934100090
• Mol file: 61636-28-0.mol

Synonyms:3-(2-Aminothiazol-4-yl)coumarin

Chemical Property of 3-(2-AMINO-1,3-THIAZOL-4-YL)-2H-CHROMEN-2-ONE HYDROBROMIDE

Chemical Property:

• Vapor Pressure: 1.39E-10mmHg at 25°C
• Boiling Point: 511.7°Cat760mmHg
• Flash Point: 263.2°C
• PSA: 98.09000
• Density: 1.487g/cm³
• LogP: 3.38690

Purity/Quality:

98%min ^*data from raw suppliers

3-(2-Amino-thiazol-4-yl)-chromen-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-(2''-Aminothiazolyl) coumarin is used in the preparation of histone deacetylase inhibitors with antifibrotic activity.

Technology Process of 3-(2-AMINO-1,3-THIAZOL-4-YL)-2H-CHROMEN-2-ONE HYDROBROMIDE

There total 7 articles about 3-(2-AMINO-1,3-THIAZOL-4-YL)-2H-CHROMEN-2-ONE HYDROBROMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-bromoacetylcoumarin (29310-88-1) + thiourea (17356-08-0) → 3-(2-amino-1,3-thiazol-4-yl)coumarin (61636-28-0)

Guidance literature:

With sodium fluoride; In methanol; water; at 20 ℃;

DOI:10.1016/j.cclet.2013.10.001

Reference yield: 80.0%

3-(2-chloro-thiazol-4-yl)-coumarin (176788-59-3) → 3-(2-amino-1,3-thiazol-4-yl)coumarin (61636-28-0)

Guidance literature:

With ammonia; In N,N-dimethyl-formamide; for 0.5h; Heating;

Reference yield: 70.0%

3-acetylcoumarin (3949-36-8) + thiourea (17356-08-0) → 3-(2-amino-1,3-thiazol-4-yl)coumarin (61636-28-0)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In benzene; for 6h; Heating;

upstream raw materials:

3-bromoacetylcoumarin

thiourea

3-(2-chloro-thiazol-4-yl)-coumarin

3-acetylcoumarin

Downstream raw materials:

3-(2-(((2-hydroxy-3,5-dibromophenyl)methylene)amino)-4-thiazolyl)-2H-1-benzopyran-2-one

3-(2-(((2-hydroxy-3-bromophenyl)methylene)amino)-4-thiazolyl)-2H-1-benzopyran-2-one

3-(2-(((p-methoxyphenyl)methylene)amino)-4-thiazolyl)-2H-1-benzopyran-2-one

3-(2-(((2-hydroxyphenyl)methylene)amino)-4-thiazolyl)-2H-1-benzopyran-2-one

Refernces

• 1、 Mahapatra, Ajit Kumar,Mondal, Sanchita,Manna, Saikat Kumar,Maiti, Kalipada,Maji, Rajkishor,Uddin, Md. Raihan,Mandal, Sukhendu,Sarkar, Deblina,Mondal, Tapan Kumar,Maiti, Dilip Kumar. "A new selective chromogenic and turn-on fluorogenic probe for copper(ii) in solution and vero cells: Recognition of sulphide by [CuL]". . p. 6490 - 6501. Retrieved 2015.
• 2、 Chellappa Subramanyam, Dwaraka Viswanath,Divi, Haranath,Godugu, Kumar,Gundala, Trivikram Reddy,Loka, Subramanyam Sarma,Mohinuddin Pinjari, Mohammad Khaja,Reddy Nallagondu, Chinna Gangi,Shaik, Sultana,Vemula, Venkatramu. "Solid state thiazole-based fluorophores: Promising materials for white organic light emitting devices". . . Retrieved 2021/01/07.
• 3、 Sonmez, Fatih,Zengin Kurt, Belma,Gazioglu, Isil,Basile, Livia,Dag, Aydan,Cappello, Valentina,Ginex, Tiziana,Kucukislamoglu, Mustafa,Guccione, Salvatore. "Design, synthesis and docking study of novel coumarin ligands as potential selective acetylcholinesterase inhibitors". . p. 285 - 297. Retrieved 2017/11/10.