rac-1-(m-chlorophenyl)-2-(tert-butylamino)-(2-²H)-propan-1-one

Base Information

• Chemical Name: rac-1-(m-chlorophenyl)-2-(tert-butylamino)-(2-²H)-propan-1-one
• CAS No.: 1132091-22-5
• Molecular Formula: C₁₃H₁₈ClNO
• Molecular Weight: 240.737
• Mol file: 1132091-22-5.mol

Synonyms:rac-1-(m-chlorophenyl)-2-(tert-butylamino)-(2-²H)-propan-1-one

Chemical Property of rac-1-(m-chlorophenyl)-2-(tert-butylamino)-(2-²H)-propan-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of rac-1-(m-chlorophenyl)-2-(tert-butylamino)-(2-²H)-propan-1-one

There total 2 articles about rac-1-(m-chlorophenyl)-2-(tert-butylamino)-(2-²H)-propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

bupropion (34841-39-9,34911-55-2,144445-75-0,144445-76-1) → rac-1-(m-chlorophenyl)-2-(tert-butylamino)-(2-2H)-propan-1-one (1132091-22-5)

Guidance literature:

With hydrogen chloride; In aq. phosphate buffer; water-d2; at 20 ℃; for 264h; pH=7;

Reference yield: 71.0%

BUPROPION HYDROCHLORIDE (31677-93-7) → rac-1-(m-chlorophenyl)-2-(tert-butylamino)-(2-2H)-propan-1-one (1132091-22-5)

Guidance literature:

With 2,2,6,6-tetramethyl-piperidine; tris(pentafluorophenyl)borate; water-d2; In chloroform; at 80 ℃; for 1h; regioselective reaction; Inert atmosphere;

DOI:10.1002/adsc.201901419

Reference yield: 86.0%

trifluoroacetic acid-d1 (599-00-8) + rac-1-(m-chlorophenyl)-2-(tert-butylamino)-(2-2H)-propan-1-one (1132091-22-5) → rac-1-(m-chlorophenyl)-2-(tert-butylamino)-(2-2H)-propan-1-one deuterated trifluoroacetic acid salt

Guidance literature:

In ethyl acetate;

upstream raw materials:

bupropion

BUPROPION HYDROCHLORIDE

Refernces

• 1、 -. "METHODS OF TREATING NEUROLOGICAL AND OTHER DISORDERS USING ENANTIOPURE DEUTERIUM-ENRICHED BUPROPION". Paragraph 00140-00141. . Retrieved 2015/07/07.