5-HYDROXYVALERAMIDE

Base Information

• Chemical Name: 5-HYDROXYVALERAMIDE
• CAS No.: 29686-12-2
• Molecular Formula: C5H11 N O2
• Molecular Weight: 117.148
• Mol file: 29686-12-2.mol

Synonyms:Valeramide,5-hydroxy- (6CI,7CI,8CI); 5-Hydroxypentanamide; 5-Hydroxyvaleramide; NSC310171; d-Hydroxypentanamide; d-Hydroxyvaleramide

Chemical Property of 5-HYDROXYVALERAMIDE

Chemical Property:

• Vapor Pressure: 9.69E-06mmHg at 25°C
• Boiling Point: 333.5°C at 760 mmHg
• Flash Point: 155.5°C
• Density: 1.071g/cm³

Purity/Quality:

99% ^*data from raw suppliers

5-Hydroxyvaleramide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-HYDROXYVALERAMIDE

There total 3 articles about 5-HYDROXYVALERAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

3,4,5,6-tetrahydro-2H-pyran-2-one (542-28-9,26354-94-9) → 5-pentanolide (29686-12-2)

Guidance literature:

With ammonia; In ethanol; at 80 ℃; for 6h; under 12929 Torr; Sealed bomb;

Reference yield:

5-hydroxy-pentanenitrile (2427-16-9) → 5-pentanolide (29686-12-2)

Guidance literature:

With manganese(IV) oxide; silica gel; In hexane; for 192h; Ambient temperature;

DOI:10.1016/S0040-4039(00)76229-0

Reference yield:

→ 5-pentanolide (29686-12-2)

Guidance literature:

5-Valerolacton, aq. NH3;

DOI:10.1021/jo01051a029

upstream raw materials:

3,4,5,6-tetrahydro-2H-pyran-2-one

5-hydroxy-pentanenitrile

Downstream raw materials:

5-{[tert-butyl(diphenyl)silyl]oxy}pentamide

piperidine-2,6-dione

5-(6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-4-(1-methylpiperidin-4-ylamino)quinazolin-7-yloxy)pentanamide

9,10-dimethoxy-1,2,3,4,6,7-hexahydrobenzoquinolizinium chloride

Refernces

• 1、 Wendt, John A.,Wu, Hongwei,Stenmark, Heather G.,Boys, Mark L.,Downs, Victoria L.,Penning, Thomas D.,Chen, Barbara B.,Wang, Yaping,Duffin, Tiffany,Finn, Mary Beth,Keene, Jeffery L.,Engleman, V. Wayne,Freeman, Sandra K.,Hanneke, Melanie L.,Shannon, Kristen E.,Nickols, Maureen A.,Steininger, Christina N.,Westlin, Marissa,Klover, Jon A.,Westlin, William,Nickols, G. Allen,Russell, Mark A.. "Synthesis of 2,5-thiazole butanoic acids as potent and selective αvβ3 integrin receptor antagonists with improved oral pharmacokinetic properties". . p. 845 - 849. Retrieved 2007/10/03.
• 2、 Breuilles,Leclerc,Uguen. "A mild hydration of nitriles into amides". . p. 1401 - 1404. Retrieved 2007/10/02.