Piperazine phosphate

Base Information

• Chemical Name: Piperazine phosphate
• CAS No.: 14538-56-8
• Molecular Formula: C4H10N2^.H3PO4
• Molecular Weight: 184.132
• Hs Code.: 2933599550
• European Community (EC) Number: 217-775-8,238-572-0
• UNII: P7S1V82385
• DSSTox Substance ID: DTXSID70932581
• Wikidata: Q27286336
• ChEMBL ID: CHEMBL2219733
• Mol file: 14538-56-8.mol

Synonyms:1,4 Diazacyclohexane;1,4 Piperazine;1,4-Diazacyclohexane;1,4-piperazine;piperazine;piperazine diacetate;piperazine dihydrochloride;piperazine hexahydrate;piperazine hydrate;piperazine hydrobromide;piperazine hydrochloride;piperazine monohydrochloride;piperazine phosphate;piperazine phosphate (1:1);Piperazine Phosphate Anhydrous;piperazine salt;piperazine sulfate;Piperazine Tartrate;piperazine tartrate (1:1), (R-(R*,R*))-isomer;piperazine tartrate, (R-(R*,R*))-isomer;piperazinium oleate;Pripsen

Chemical Property of Piperazine phosphate

Chemical Property:

• Appearance/Colour: Gray power
• Vapor Pressure: 4.36E-10mmHg at 25°C
• Melting Point: 224-226 °C
• Boiling Point: 468.9 °C at 760 mmHg
• Flash Point: 237.4 °C
• PSA: 111.63000
• LogP: -1.09180
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 0
• Exact Mass: 184.06129390
• Heavy Atom Count: 11
• Complexity: 76.3

Purity/Quality:

99% ^*data from raw suppliers

Piperazine Phosphate Monohydrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNCCN1.OP(=O)(O)O
• Uses: Piperazine Phosphate Monohydrate is used as an anthelmintic agent in the treatment of parasitic worm infections. Piperazine (P479900) derivatives are known to have high antiserotonin potency, antimicrobial activity, and potential anticancer activity in humans.

Technology Process of Piperazine phosphate

There total 3 articles about Piperazine phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

piperazine (110-85-0) → piperazine hydrogen phosphate (14538-56-8)

Guidance literature:

With phosphoric acid; In water; for 5h;

DOI:10.1016/j.saa.2012.10.004

Reference yield:

piperazine (110-85-0) → piperazine diphosphate (1951-97-9,14538-56-8,52978-33-3,74592-75-9)

Guidance literature:

With phosphoric acid; In water; at 70 ℃; for 1h; Microwave irradiation;

Reference yield:

piperazine (110-85-0) + phosphoric acid (86119-84-8,7664-38-2) → piperazine diphosphate (1951-97-9,14538-56-8,52978-33-3,74592-75-9)

Guidance literature:

In methanol; water; at 200 - 250 ℃;

upstream raw materials:

piperazine

phosphoric acid

Downstream raw materials:

melamine pyrophosphate

piperazine pyrophosphate

Refernces

• 1、 -. "Microwave-assisted synthetic method of pyrophosphate piperazine". Paragraph 0014; 0016. . Retrieved 2017/02/09.
• 2、 -. "High purity pyrophosphorate piperazinecarboxylic and flame retardant synthetic resin composition". Paragraph 0017; 0018. . Retrieved 2016/12/22.