AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATE

Base Information

• Chemical Name: AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATE
• CAS No.: 106566-58-9
• Molecular Formula: C₂H₄Cl₃O₂Te*H₄N
• Molecular Weight: 316.018
• Mol file: 106566-58-9.mol

Synonyms:Tellurate(1-),trichloro[1,2-ethanediolato(2-)-O,O']-, ammonium, (SP-5-22)-; 1,2-Ethanediol,tellurium complex; AS 101; AS 101 (pharmaceutical); Ossirene

Chemical Property of AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATE

Chemical Property:

• Boiling Point: 197.5°Cat760mmHg
• Flash Point: 108.2°C
• PSA: 18.46000
• Density: 1.097g/cm³
• LogP: 2.01210
• Storage Temp.: Desiccate at RT
• Solubility.: Soluble in DMSO

Purity/Quality:

98%Min ^*data from raw suppliers

AS 101 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: AS 101 inhibits AKT activity in leukemic cells and has bee shown to favorably affect renal pathologies in various animal models. AS 101 inhibition of the AKT downstream pathway by AS101 has clinical potential in alleviating the progression of diabetic nephropathy.

Technology Process of AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATE

There total 2 articles about AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

ethylene glycol (107-21-1) → ammonium trichloro(1,2-dioxoethane-O,O')tellurate(IV) (106566-58-9,137681-44-8)

Guidance literature:

With tellurium tetrachloride; In acetonitrile; for 4h; Heating;

DOI:10.1055/s-1989-27344

Reference yield:

ethylene glycol-d2 (2219-52-5) → perdeuteroammonium trichloro(1,2-dioxoethane-O,O')tellurate(IV) (106566-58-9,137681-44-8)

Guidance literature:

With tellurium tetrachloride; In acetonitrile; at 92 ℃; for 4h;

upstream raw materials:

ethylene glycol

ethylene glycol-d2

Refernces

• 1、 Albeck, M.,Tamari, T.,Sredni, B.. "Synthesis and Properties of Ammonium Trichloro(dioxyethylene-O,O')tellurate (AS-101). A New Immunomodulating Compound". . p. 635 - 636. Retrieved 2007/10/02.