3-benzyloxy-2-nitrobenzoic acid methyl ester

Base Information

• Chemical Name: 3-benzyloxy-2-nitrobenzoic acid methyl ester
• CAS No.: 533897-93-7
• Molecular Formula: C₁₅H₁₃NO₅
• Molecular Weight: 287.272
• Mol file: 533897-93-7.mol

Synonyms:3-benzyloxy-2-nitrobenzoic acid methyl ester

Chemical Property of 3-benzyloxy-2-nitrobenzoic acid methyl ester

Chemical Property:

Purity/Quality:

More than 98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-benzyloxy-2-nitrobenzoic acid methyl ester

There total 2 articles about 3-benzyloxy-2-nitrobenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methyl 3-hydroxy-2-nitrobenzoate (89942-77-8) + benzyl bromide (100-39-0) → 3-benzyloxy-2-nitrobenzoic acid methyl ester (533897-93-7)

Guidance literature:

With potassium carbonate; In methanol; dichloromethane; for 8h; Inert atmosphere; Reflux;

DOI:10.1021/jm801241n

Reference yield:

3-hydroxy-2-nitrobenzoic acid (602-00-6) → 3-benzyloxy-2-nitrobenzoic acid methyl ester (533897-93-7)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol. H₂SO₄

2: methanol. NaOH

With sodium hydroxide; sulfuric acid;

Reference yield: 94.0%

3-benzyloxy-2-nitrobenzoic acid methyl ester (533897-93-7) → 3-benzyloxy-2-nitrobenzoic acid (24115-89-7)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; for 3h; Reflux;

DOI:10.1021/jm801241n

upstream raw materials:

3-hydroxy-2-nitrobenzoic acid

methyl 3-hydroxy-2-nitrobenzoate

benzyl bromide

Downstream raw materials:

3-benzyloxy-2-nitrobenzoic acid

2-nitro-3-benzyloxybenzoyl chloride

N-(2-amino-3-hydroxy-benzoyl)-glycine

N-(3-benzyloxy-2-nitro-benzoyl)-glycine

Refernces

• 1、 Tipparaju, Suresh K.,Joyasawal, Sipak,Pieroni, Marco,Kaiser, Marcel,Brun, Reto,Kozikowski, Alan P.. "In pursuit of natural product leads: Synthesis and biological evaluation of 2-[3-hydroxy-2-[(3-hydroxypyridine-2-carbonyl)amino]phenyl]benzoxazole-4- carboxylic acid (A-33853) and its analogues: Discovery of N-(2-benzoxazol-2- ylphenyl)benzamides as novel". supporting information; experimental part. p. 7344 - 7347. Retrieved 2009/12/07.