Sorbitan monolaurate

Base Information

• Chemical Name: Sorbitan monolaurate
• CAS No.: 5959-89-7
• Deprecated CAS: 53528-77-1,55070-12-7,76011-50-2,8028-02-2,507483-77-4
• Molecular Formula: C₁₈H₃₄O₆
• Molecular Weight: 346.464
• European Community (EC) Number: 227-729-9,215-663-3,617-034-2
• UNII: 6W9PS8B71J
• DSSTox Substance ID: DTXSID9027609
• Nikkaji Number: J223.909D
• Wikipedia: Sorbitan_monolaurate
• NCI Thesaurus Code: C75653
• RXCUI: 1363055
• ChEMBL ID: CHEMBL3706389
• Mol file: 5959-89-7.mol

Synonyms:sorbitan monolaurate;Span 20

Chemical Property of Sorbitan monolaurate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 516.121°C at 760 mmHg
• Flash Point: 176.947°C
• PSA: 96.22000
• Density: 1.123g/cm³
• LogP: 1.93200
• XLogP3: 3.7
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 14
• Exact Mass: 346.23553880
• Heavy Atom Count: 24
• Complexity: 336

Purity/Quality:

99% ^*data from raw suppliers

6-Dodecanoate-1,4-anhydro-D-glucitol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Chemical Classes: Other Uses -> Emulsifiers/Surfactants
• Canonical SMILES: CCCCCCCCCCCC(=O)OCC(C1C(C(CO1)O)O)O
• Isomeric SMILES: CCCCCCCCCCCC(=O)OC[C@H]([C@@H]1[C@@H]([C@H](CO1)O)O)O
• Uses: 6-Dodecanoate-1,4-anhydro-D-glucitol is used in the synthetic preparation of nonionic surfactant.

Technology Process of Sorbitan monolaurate

There total 3 articles about Sorbitan monolaurate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

lauric acid (143-07-7) + 1,4-anhydro-D-glucitol (7726-97-8,10334-28-8,20662-31-1,22554-76-3,22554-77-4,22554-79-6,27299-12-3,28218-56-6,32742-35-1,40026-08-2,51196-40-8,51607-77-3,53648-56-9,96243-58-2,124379-08-4,124379-13-1) → Span 20 (120200-78-4,16287-68-6,5959-89-7)

Guidance literature:

With lipase; In hexane; tert-butyl alcohol; at 64 ℃; Enzymatic reaction;

DOI:10.1039/c5gc02131f

Reference yield:

D-sorbitol (50-70-4) → Span 20 (120200-78-4,16287-68-6,5959-89-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid; water / 74 h / 104 °C

2: lipase / tert-butyl alcohol; hexane / 64 °C / Enzymatic reaction

With sulfuric acid; water; lipase; In hexane; tert-butyl alcohol;

DOI:10.1039/c5gc02131f

Reference yield:

→ Span 20 (120200-78-4,16287-68-6,5959-89-7)

Guidance literature:

upstream raw materials:

lauric acid

1,4-anhydro-D-glucitol

D-sorbitol

Refernces

• 1、 -. "PRECIPITATION POLYMERIZATION IN THE PRESENCE OF GLYCERIN MONOSTEARATE". . . Retrieved 2011/06/28.
• 2、 -. "Phospholipid-and cholestrol-free aqueous composition for topical application to the skin". . . Retrieved 2008/06/13.