Sodium dehydrocholate

Base Information

• Chemical Name: Sodium dehydrocholate
• CAS No.: 145-41-5
• Molecular Formula: C24H34O5.Na
• Molecular Weight: 424.513
• Mol file: 145-41-5.mol

Synonyms:5b-Cholan-24-oic acid,3,7,12-trioxo-, sodium salt (8CI);Dehydrocholic acid sodium salt (6CI);Biliron;Biliton;Carachol;Decholin sodium;Decholin sodium salt;Dehydrocholatesodium;Dilabil sodium;Dycholium;Sodium 3,7,12-triketocholanate;Sodium3,7,12-trioxo-5b-cholanate;

Chemical Property of Sodium dehydrocholate

Chemical Property:

• Appearance/Colour: COA
• Melting Point: >300°C
• Refractive Index: 27 ° (C=5, H2O)
• Boiling Point: 581.5°C at 760mmHg
• Flash Point: 319.5°C
• PSA: 91.34000
• LogP: 2.73860
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: H2O: 0.1 M at 20 °C, clear, colorless

Purity/Quality:

99% ^*data from raw suppliers

Sodium Deoxycholate Monohydrate ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-37
• Safety Statements: 22-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: glycopeptide antibiotic complex from Actinoplanes teichomyceticus, structurally related to vancomycin, comprised of 5 major components differentiated by a specific fatty acid moiety. It inhibits peptidoglycan synthesis in the cell wall of gram-positive ba choleretic Sodium Dehydrocholate is a compound used to study biliary excretion.

Technology Process of Sodium dehydrocholate

There total 2 articles about Sodium dehydrocholate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C34H50O10 + diethyl (2R,3R)-tartrate (87-91-2) + 3,7,12-trioxo-5β-cholan-24-oic acid ethyl ester (52718-49-7) → C28H35O10(3-)*3Na(1+) + Biliton (145-41-5) + sodium L-tartrate (526-94-3,868-18-8,4504-50-1,14475-11-7,21106-15-0,21348-52-7,21595-79-9,22476-77-3,25817-08-7,51307-92-7,60131-40-0,64183-71-7,109175-69-1)

Guidance literature:

With methanol; sodium hydroxide; water;

Reference yield:

→ dehydrocholic acid sodium salt (145-41-5)

Guidance literature:

Pseudo-dehydrocholsaeure-dinatriumsalz, Wasser, 70grad;

DOI:10.1007/BF00902712

Reference yield: 50.0%

triphenylsulfonium 2-(4-chlorobutyryloxy)-1,1,3,3,3-pentafluoropropane-1-sulfonate (1126206-31-2) + Biliton (145-41-5) → triphenylsulfonium 2-{4-[4-(10,13-dimethyl-3,7,12-trioxo-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoyloxy]-butyryloxy}-1,1,3,3,3-pentafluoropropane-1-sulfonate

Guidance literature:

With sodium iodide; In N,N-dimethyl-formamide; at 80 ℃; for 11h;

upstream raw materials:

diethyl (2R,3R)-tartrate

3,7,12-trioxo-5β-cholan-24-oic acid ethyl ester

Downstream raw materials:

methyl 3α-hydroxy-7,12-dioxo-5β-cholan-24-oate

C₂₈H₃₈O₁₀

dehydrocholic acid

Refernces