Technology Process of 8-bromo-7-(2-(2,6-dimethylphenyl)-2-oxoethyl)-3-methyl-1H-purine-2,6(3H,7H)-dione
There total 2 articles about 8-bromo-7-(2-(2,6-dimethylphenyl)-2-oxoethyl)-3-methyl-1H-purine-2,6(3H,7H)-dione which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-methyl-8-bromoxanthine;
With
N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 25 ℃;
for 0.0833333h;
Inert atmosphere;
Schlenk technique;
2-bromo-2',6'-dimethylacetophenone;
In
N,N-dimethyl-formamide;
at 110 ℃;
for 2h;
Inert atmosphere;
Schlenk technique;
DOI:10.1021/jm301187e
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere; Schlenk technique
1.2: 1 h / -78 °C / Inert atmosphere; Schlenk technique
2.1: pyridinium chlorochromate / dichloromethane / 1 h / 25 °C / Inert atmosphere; Schlenk technique
3.1: copper(I) bromide / chloroform; ethyl acetate / 10 h / Inert atmosphere; Schlenk technique; Reflux
4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.08 h / 25 °C / Inert atmosphere; Schlenk technique
4.2: 2 h / 110 °C / Inert atmosphere; Schlenk technique
With
n-butyllithium; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; copper(I) bromide;
In
tetrahydrofuran; hexane; dichloromethane; chloroform; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm301187e
- Guidance literature:
-
In
ethanol;
at 175 ℃;
for 2h;
Sealed tube;
Schlenk technique;
Inert atmosphere;
DOI:10.1021/jm301187e