(4-methoxyphenyl)(tetrazol-5-yl)methyl phenyl ketone

Base Information

• Chemical Name: (4-methoxyphenyl)(tetrazol-5-yl)methyl phenyl ketone
• CAS No.: 355116-21-1
• Molecular Formula: C₁₆H₁₄N₄O₂
• Molecular Weight: 294.313
• Mol file: 355116-21-1.mol

Synonyms:(4-methoxyphenyl)(tetrazol-5-yl)methyl phenyl ketone

Chemical Property of (4-methoxyphenyl)(tetrazol-5-yl)methyl phenyl ketone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-methoxyphenyl)(tetrazol-5-yl)methyl phenyl ketone

There total 3 articles about (4-methoxyphenyl)(tetrazol-5-yl)methyl phenyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.5%

[1-cyano-1-(4-methoxypheny)-methyl] phenyl ketone (5219-04-5) → (4-methoxyphenyl)(tetrazol-5-yl)methyl phenyl ketone (355116-21-1)

Guidance literature:

With aluminium trichloride; sodium azide; In tetrahydrofuran; for 156h; Heating;

DOI:10.1039/b005286h

Reference yield:

benzoic acid methyl ester (93-58-3,5705-52-2,80226-58-0) → (4-methoxyphenyl)(tetrazol-5-yl)methyl phenyl ketone (355116-21-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / NaH / tetrahydrofuran / Heating

2: 24.5 percent / NaN₃; AlCl₃ / tetrahydrofuran / 156 h / Heating

With aluminium trichloride; sodium azide; sodium hydride; In tetrahydrofuran;

DOI:10.1039/b005286h

Reference yield:

p-methoxybenzylnitrile (104-47-2) → (4-methoxyphenyl)(tetrazol-5-yl)methyl phenyl ketone (355116-21-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / NaH / tetrahydrofuran / Heating

2: 24.5 percent / NaN₃; AlCl₃ / tetrahydrofuran / 156 h / Heating

With aluminium trichloride; sodium azide; sodium hydride; In tetrahydrofuran;

DOI:10.1039/b005286h

upstream raw materials:

[1-cyano-1-(4-methoxypheny)-methyl] phenyl ketone

benzoic acid methyl ester

p-methoxybenzylnitrile

Downstream raw materials:

3-(4-methoxyphenyl)-1-phenylprop-2-yn-1-one

Refernces