Terizidone

Base Information

• Chemical Name: Terizidone
• CAS No.: 25683-71-0
• Molecular Formula: C14H14N4O4
• Molecular Weight: 302.29
• European Community (EC) Number: 247-186-1
• UNII: 1199LEX5N8
• DSSTox Substance ID: DTXSID30865245,DTXSID70905098
• Nikkaji Number: J20.143J
• Wikipedia: Terizidone
• Wikidata: Q1318344
• NCI Thesaurus Code: C90772
• ChEMBL ID: CHEMBL2107553
• Mol file: 25683-71-0.mol

Synonyms:4,4'-(p-phenylenebis(methyleneimino))bis-3-isoxazolidone;terazolidone;Terivalidin;Terivalidine;Terizidon;terizidone;terizidone, calcium salt, (R-(R*,R*))-isomer

Chemical Property of Terizidone

Chemical Property:

• Melting Point: 204-205℃
• Refractive Index: 1.691
• PKA: 14.08±0.40(Predicted)
• PSA: 101.38000
• Density: 1.52
• LogP: 0.04200
• Storage Temp.: Refrigerator, Under Inert Atmosphere
• Solubility.: DMSO (Slightly, Heated), Methanol (Slightly, Heated)
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 4
• Exact Mass: 302.10150494
• Heavy Atom Count: 22
• Complexity: 441

Purity/Quality:

99%min, ^*data from raw suppliers

Terizidone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1C(C(=O)NO1)N=CC2=CC=C(C=C2)C=NC3CONC3=O
• Recent ClinicalTrials: An Open-label RCT to Evaluate a New Treatment Regimen for Patients With Multi-drug Resistant Tuberculosis
• Uses: TERIZIDONE is a drug used to treat tuberculosis. A drug used to treat tuberculosis.

Technology Process of Terizidone

There total 1 articles about Terizidone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 4,4'-{1,4-phenylenebis(methylidynenitrilo)}bis(isoxazolidin-3-one) (25683-71-0)

Guidance literature:

DL-4-Amino-3-isoxazolidon,Terephthaldehyd;

Reference yield:

4,4'-{1,4-phenylenebis(methylidynenitrilo)}bis(isoxazolidin-3-one) (25683-71-0) + rhodium triiodide (15492-38-3) → Rh(trz)3I3*2H2O

Guidance literature:

In acetone; reflux;

DOI:10.1071/CH9821829